NLRC5：回归先天免疫

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2024-07-31 DOI:10.1016/j.it.2024.07.002

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引用次数: 0

摘要

NLRC5 是调节 T 细胞反应基因的转录调节器。大多数具有特征的 NLRs 都是先天性免疫传感器，它们形成的复合物会导致细胞凋亡。Sundaram 及其同事现在证明，NLRC5 在炎症环境中对血红素做出反应时，会形成大型复合物并导致细胞凋亡（免疫性细胞死亡），这提出了令人兴奋的问题。

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NLRC5: back to innate immunity

NLRC5 is a transcriptional regulator of genes governing T cell responses. Most characterized NLRs are instead innate immune sensors forming complexes leading to pyroptosis. Raising exciting questions, Sundaram and colleagues now demonstrate that NLRC5 forms large complexes and causes PANoptosis (immunogenic cell death), in response to heme in inflammatory contexts.

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.