甘氨酸改性铅笔石墨电极作为咖啡因测定传感器：伏安法研究

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-30 DOI:10.2174/0115734110324545240725114425

Şeyma Korkmaz, Wael Bosnali, Hafizullah Sharifi, İbrahim Ender Mülazımoğlu, Ayşen Demir Mülazımoğlu

{"title":"甘氨酸改性铅笔石墨电极作为咖啡因测定传感器：伏安法研究","authors":"Şeyma Korkmaz, Wael Bosnali, Hafizullah Sharifi, İbrahim Ender Mülazımoğlu, Ayşen Demir Mülazımoğlu","doi":"10.2174/0115734110324545240725114425","DOIUrl":null,"url":null,"abstract":"Background: Caffeine (CAF) is a widely used chemical in foods and pharmaceuticals that is consumed by a lot of people every day. Overconsumption of caffeine can lead to some undesirable symptoms. However, CAF is considered a crucial nervous system stimulant. Aims: This study aimed to find an accurate and effective route for determining caffeine using voltammetric techniques. Objective: In this work, for the first time, a glycine (Gly) modified pencil graphite electrode (Gly/PGE) was used for the determination of caffeine (CAF) by Square Wave Adsorptive Stripping Voltammetry (SWAdSV) technique. Methods: The modification procedure of PGE by Gly was accomplished by performing the cyclic voltammetry (CV) technique for 10 cycles at a potential range of 0.8 to 1.8 V. Moreover, the characterization of Gly/PGE was done by applying the CV technique in aqueous and non-aqueous media and electrochemical impedance spectroscopy (EIS) in addition to the SEM technique. The movement type of CAF toward Gly/PGE was proven to be a diffusion-controlled process by conducting some measurements at different scan rates. The supporting electrolyte for the determination of CAF was studied, where 100 mM of sulfuric acid (H2SO4) provided the best result. Optimization of accumulation time, pulse size, and wave frequency were implemented and found to be 60 s accumulation time, 50 mV pulse size, and 25 Hz wave frequency. The stability of Gly/PGE was studied in different mediums, such as air, ultrapure water, and acetonitrile (CH3CN). Results: The determination of CAF under optimum conditions was within the linear concentration range of 0.1–75 μM, with a correlation coefficient of R2 = 0.9990. The limit of detection (LOD) and limit of quantification (LOQ) were 0.070 and 0.231 μM, respectively. Conclusion: An effective voltammetric methodology was suggested to determine CAF. This methodology has great promise to be applied in different matrices to determine CAF.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Glycine-modified Pencil Graphite Electrode as a Sensor for Caffeine Determination: A Voltammetric Study\",\"authors\":\"Şeyma Korkmaz, Wael Bosnali, Hafizullah Sharifi, İbrahim Ender Mülazımoğlu, Ayşen Demir Mülazımoğlu\",\"doi\":\"10.2174/0115734110324545240725114425\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Caffeine (CAF) is a widely used chemical in foods and pharmaceuticals that is consumed by a lot of people every day. Overconsumption of caffeine can lead to some undesirable symptoms. However, CAF is considered a crucial nervous system stimulant. Aims: This study aimed to find an accurate and effective route for determining caffeine using voltammetric techniques. Objective: In this work, for the first time, a glycine (Gly) modified pencil graphite electrode (Gly/PGE) was used for the determination of caffeine (CAF) by Square Wave Adsorptive Stripping Voltammetry (SWAdSV) technique. Methods: The modification procedure of PGE by Gly was accomplished by performing the cyclic voltammetry (CV) technique for 10 cycles at a potential range of 0.8 to 1.8 V. Moreover, the characterization of Gly/PGE was done by applying the CV technique in aqueous and non-aqueous media and electrochemical impedance spectroscopy (EIS) in addition to the SEM technique. The movement type of CAF toward Gly/PGE was proven to be a diffusion-controlled process by conducting some measurements at different scan rates. The supporting electrolyte for the determination of CAF was studied, where 100 mM of sulfuric acid (H2SO4) provided the best result. Optimization of accumulation time, pulse size, and wave frequency were implemented and found to be 60 s accumulation time, 50 mV pulse size, and 25 Hz wave frequency. The stability of Gly/PGE was studied in different mediums, such as air, ultrapure water, and acetonitrile (CH3CN). Results: The determination of CAF under optimum conditions was within the linear concentration range of 0.1–75 μM, with a correlation coefficient of R2 = 0.9990. The limit of detection (LOD) and limit of quantification (LOQ) were 0.070 and 0.231 μM, respectively. Conclusion: An effective voltammetric methodology was suggested to determine CAF. This methodology has great promise to be applied in different matrices to determine CAF.\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-07-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.2174/0115734110324545240725114425\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2174/0115734110324545240725114425","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

背景：咖啡因（CAF）是一种广泛应用于食品和药品的化学物质，每天都有很多人摄入。过量摄入咖啡因会导致一些不良症状。然而，咖啡因被认为是一种重要的神经系统兴奋剂。目的：本研究旨在找到一种利用伏安法测定咖啡因的准确而有效的方法。目的：本研究首次采用伏安法测定咖啡因：本研究首次使用甘氨酸（Gly）修饰的铅笔石墨电极（Gly/PGE），通过方波吸附剥离伏安法（SWAdSV）技术测定咖啡因（CAF）。方法：通过在 0.8 至 1.8 V 的电位范围内进行 10 个循环的循环伏安（CV）技术，完成了 Gly 对 PGE 的改性过程。此外，除了扫描电镜技术外，还在水介质和非水介质中应用了 CV 技术和电化学阻抗光谱（EIS）技术对 Gly/PGE 进行了表征。通过在不同扫描速率下进行一些测量，证明了 CAF 向 Gly/PGE 的移动类型是一个扩散控制过程。研究了测定 CAF 的辅助电解质，其中 100 mM 的硫酸 (H2SO4) 效果最佳。对累积时间、脉冲大小和波频进行了优化，发现累积时间为 60 秒，脉冲大小为 50 mV，波频为 25 Hz。研究了 Gly/PGE 在不同介质（如空气、超纯水和乙腈 (CH3CN)）中的稳定性。结果显示在最佳条件下，CAF 的测定在 0.1-75 μM 的线性浓度范围内，相关系数为 R2 = 0.9990。检出限（LOD）和定量限（LOQ）分别为 0.070 和 0.231 μM。结论提出了一种有效的伏安法测定 CAF。该方法有望应用于不同基质中的 CAF 检测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Glycine-modified Pencil Graphite Electrode as a Sensor for Caffeine Determination: A Voltammetric Study

Background: Caffeine (CAF) is a widely used chemical in foods and pharmaceuticals that is consumed by a lot of people every day. Overconsumption of caffeine can lead to some undesirable symptoms. However, CAF is considered a crucial nervous system stimulant. Aims: This study aimed to find an accurate and effective route for determining caffeine using voltammetric techniques. Objective: In this work, for the first time, a glycine (Gly) modified pencil graphite electrode (Gly/PGE) was used for the determination of caffeine (CAF) by Square Wave Adsorptive Stripping Voltammetry (SWAdSV) technique. Methods: The modification procedure of PGE by Gly was accomplished by performing the cyclic voltammetry (CV) technique for 10 cycles at a potential range of 0.8 to 1.8 V. Moreover, the characterization of Gly/PGE was done by applying the CV technique in aqueous and non-aqueous media and electrochemical impedance spectroscopy (EIS) in addition to the SEM technique. The movement type of CAF toward Gly/PGE was proven to be a diffusion-controlled process by conducting some measurements at different scan rates. The supporting electrolyte for the determination of CAF was studied, where 100 mM of sulfuric acid (H2SO4) provided the best result. Optimization of accumulation time, pulse size, and wave frequency were implemented and found to be 60 s accumulation time, 50 mV pulse size, and 25 Hz wave frequency. The stability of Gly/PGE was studied in different mediums, such as air, ultrapure water, and acetonitrile (CH3CN). Results: The determination of CAF under optimum conditions was within the linear concentration range of 0.1–75 μM, with a correlation coefficient of R2 = 0.9990. The limit of detection (LOD) and limit of quantification (LOQ) were 0.070 and 0.231 μM, respectively. Conclusion: An effective voltammetric methodology was suggested to determine CAF. This methodology has great promise to be applied in different matrices to determine CAF.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.