ATP驱动的提取器ATAD1/Msp1校对蛋白质转运到线粒体的过程

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2024-08-01 DOI:10.1016/j.tcb.2024.07.007

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引用次数: 0

摘要

线粒体导入机制中转运中间体的积累会威胁细胞的健康，并与癌症和神经变性有关。Weidberg 及其同事最近的一项研究发现，ATAD1 是线粒体表面由 ATP 驱动的提取机器，它能将前体拉入细胞质，防止线粒体导入孔堵塞。

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The ATP-driven extractor ATAD1/Msp1 proof-reads protein translocation into mitochondria

The accumulation of translocation intermediates in the mitochondrial import machinery threatens cellular fitness and is associated with cancer and neurodegeneration. A recent study by Weidberg and colleagues identifies ATAD1 as an ATP-driven extraction machine on the mitochondrial surface that pulls precursors into the cytosol to prevent clogging of mitochondrial import pores.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.