点阵二氧化碳激光对人类黑色素细胞和白癜风小鼠模型黑色素生成的影响

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-01 DOI:10.2147/ccid.s445131

Hui Tang, Xiaoxia Ding, Youming Huang, Danfeng Xu, Yibin Fan

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引用次数: 0

摘要

简介白癜风是一种后天性皮肤色素脱失症，病因尚不清楚。该领域的研究人员致力于探索实现色素再沉着的新型疗法：方法：随机选择小鼠，将其分为对照组、模型组和模型+激光组。评估不同程度的二氧化碳激光照射对酪氨酸酶活性、黑色素细胞活力和黑色素含量的影响：结果：研究发现，使用不同能量密度的点阵二氧化碳激光治疗后，人类黑色素细胞的细胞活力和黑色素含量均显著提高。此外，经激光治疗的白癜风小鼠模型出现了轻微的病理变化：因此，我们认为点阵二氧化碳激光可能是治疗白癜风的一种潜在的辅助方法。关键词：白癜风；点阵二氧化碳激光；黑色素细胞；黑色素生成；白癜风小鼠模型

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The Effect of Fractional Carbon Dioxide Laser on Melanogenesis in Human Melanocytes and Vitiligo Mouse Models

Introduction: Vitiligo is an acquired skin pigmentation disorder, the cause of which is poorly understood. Researchers in this field are dedicated to exploring novel treatments for achieving re-pigmentation.
Methods: Mice were randomly selected and divided into control, model, and model+laser groups. Evaluate the impact of different levels of carbon dioxide laser irradiation on tyrosinase activity, melanocyte viability, and melanin content.
Results: In this study, it was found that the cell viability and melanin content were significantly enhanced in human melanocytes after treatment with different energy densities of fractional carbon dioxide laser. In addition, laser-treated vitiligo mouse models showed mild pathological changes.
Discussion: Therefore, we believe that fractional carbon dioxide laser may be a potential adjunctive modality for treating vitiligo.

Keywords: vitiligo, fractional carbon dioxide laser, melanocytes, melanogenesis, vitiligo mouse models

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.