点阵二氧化碳激光对人类黑色素细胞和白癜风小鼠模型黑色素生成的影响

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-08-01 DOI:10.2147/ccid.s445131

Hui Tang, Xiaoxia Ding, Youming Huang, Danfeng Xu, Yibin Fan

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引用次数: 0

摘要

简介白癜风是一种后天性皮肤色素脱失症，病因尚不清楚。该领域的研究人员致力于探索实现色素再沉着的新型疗法：方法：随机选择小鼠，将其分为对照组、模型组和模型+激光组。评估不同程度的二氧化碳激光照射对酪氨酸酶活性、黑色素细胞活力和黑色素含量的影响：结果：研究发现，使用不同能量密度的点阵二氧化碳激光治疗后，人类黑色素细胞的细胞活力和黑色素含量均显著提高。此外，经激光治疗的白癜风小鼠模型出现了轻微的病理变化：因此，我们认为点阵二氧化碳激光可能是治疗白癜风的一种潜在的辅助方法。关键词：白癜风；点阵二氧化碳激光；黑色素细胞；黑色素生成；白癜风小鼠模型

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The Effect of Fractional Carbon Dioxide Laser on Melanogenesis in Human Melanocytes and Vitiligo Mouse Models

Introduction: Vitiligo is an acquired skin pigmentation disorder, the cause of which is poorly understood. Researchers in this field are dedicated to exploring novel treatments for achieving re-pigmentation.
Methods: Mice were randomly selected and divided into control, model, and model+laser groups. Evaluate the impact of different levels of carbon dioxide laser irradiation on tyrosinase activity, melanocyte viability, and melanin content.
Results: In this study, it was found that the cell viability and melanin content were significantly enhanced in human melanocytes after treatment with different energy densities of fractional carbon dioxide laser. In addition, laser-treated vitiligo mouse models showed mild pathological changes.
Discussion: Therefore, we believe that fractional carbon dioxide laser may be a potential adjunctive modality for treating vitiligo.

Keywords: vitiligo, fractional carbon dioxide laser, melanocytes, melanogenesis, vitiligo mouse models

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.