前沿 | 滑液的流变行为:数学挑战

IF 2.6 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY
Noureddine Ouerfelli, Narcisa Vrinceanu, Ezzedine Mliki, Kamal A. Amin, Lotfi Snoussi, Diana Coman, Dalila Mrabet
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引用次数: 0

摘要

背景由于滑膜液(SF)能反映局部炎症环境,因此常用于诊断和研究。由于其成分复杂,特别是含有透明质酸,鞘磷脂通常是粘稠和不均匀的。由于这种液体中含有高摩尔质量的透明质酸,因此具有作为润滑剂所需的粘度。粘度是关节软骨中 SF 最大的主要水力特性。在这项研究中,我们探讨了可用于模拟 SF 流动的非牛顿流体的流动。分析简单几何形状中的流动有助于解释模型的有效性和评估 SF 模型。通过采用其他地方报道的一些粘度数据,我们总结了正常人膝关节 SF 在 25°C 注射透明质酸酶(HYAL)后随时间变化的动态粘度值。通过外推法得出了所建议的二次方行为。为了准确诊断或预测,在相同的实验条件下,对正常和病理病例的三个特定参数(ai、t0 和 ln η0)进行了比较,以便通过添加 HYAL 进行治疗和研究流变特性。结果膝关节 SF 的流变行为随着时间的推移从非牛顿型逐渐转变为牛顿型,其中粘度在特定的特征时间(t0 ≈ 8.5 h)具有与梯度速度无关的极限恒定值(η0)。所提出的具有物理意义的三参数模型为未来的病理病例提供了启示。通过与 HYAL 注入相同实验条件下处理的新参数值进行比较,这项工作的成果有望为病理病例类型的诊断、标准和预测提供新的视角。本研究还强调了 HYAL 处理对于提高检测精度的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Frontiers | Rheological behavior of the synovial fluid: a mathematical challenge
BackgroundSynovial fluid (SF) is often used for diagnostic and research purposes as it reflects the local inflammatory environment. Owing to its complex composition, especially the presence of hyaluronic acid, SF is usually viscous and non-homogeneous. The presence of high-molar-mass hyaluronan in this fluid gives it the required viscosity for its function as a lubricant. Viscosity is the greatest major hydraulic attribute of the SF in articular cartilage.MethodsEmpirical modeling of previously published results was performed. In this study, we explored the flow of a non-Newtonian fluid that could be used to model the SF flow. Analyzing the flow in a simple geometry can help explain the model’s efficacy and assess the SF models. By employing some viscosity data reported elsewhere, we summarized the dynamic viscosity values of normal human SF of the knee joints in terms of time after injecting hyaluronidase (HYAL) at 25°C. The suggested quadratic behavior was obtained through extrapolation. For accurate diagnosis or prediction, the comparison between three specific parameters (ai, t0, and ln η0) was made for normal and pathological cases under the same experimental conditions for treatment by addition of HYAL and for investigation of the rheological properties. A new model on the variation of viscosity on the SF of knee joints with time after injection of HYAL with respect to normal and postmortem samples at different velocity gradients was proposed using data previously reported elsewhere.ResultsThe rheological behavior of SF changes progressively over time from non-Newtonian to a Newtonian profile, where the viscosity has a limiting constant value (η0) independent of the gradient velocity at a unique characteristic time (t0 ≈ 8.5 h). The proposed three-parameter model with physical meaning offers insights into future pathological cases. The outcomes of this work are expected to offer new perspectives for diagnosis, criteria, and prediction of pathological case types through comparisons with new parameter values treated under the same experimental conditions as HYAL injection. This study also highlights the importance of HYAL treatment for better intra-assay precision.
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来源期刊
Frontiers in Materials
Frontiers in Materials Materials Science-Materials Science (miscellaneous)
CiteScore
4.80
自引率
6.20%
发文量
749
审稿时长
12 weeks
期刊介绍: Frontiers in Materials is a high visibility journal publishing rigorously peer-reviewed research across the entire breadth of materials science and engineering. This interdisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers across academia and industry, and the public worldwide. Founded upon a research community driven approach, this Journal provides a balanced and comprehensive offering of Specialty Sections, each of which has a dedicated Editorial Board of leading experts in the respective field.
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