P. D. Orlova, I. B. Meshkov, E. V. Latipov, S. G. Vasil’ev, A. A. Kalinina, A. M. Muzafarov, I. M. Le-Deygen
{"title":"用于治疗缺铁性贫血的基于聚甲基硅倍半氧烷水凝胶的口腔周围铁化合物输送系统的功能设计","authors":"P. D. Orlova, I. B. Meshkov, E. V. Latipov, S. G. Vasil’ev, A. A. Kalinina, A. M. Muzafarov, I. M. Le-Deygen","doi":"10.1134/s0036023624600266","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>An approach to the development of peroral iron drug delivery systems for the therapy of iron deficiency anemia is proposed. The new systems are based on polymethylsilsesquioxane hydrogels with a variable structure as biocompatible and biodegradable supports. The hydrogels are found to exhibit a high sorption capacity toward a saturated solution of FeCl<sub>3</sub>∙6H<sub>2</sub>O (0.27 M), whereas the sorption capacity toward a saturated solution of iron D-gluconate (0.24 M) is lower and amounts to ~30%. The developed delivery systems are studied by IR and UV spectroscopy, and the iron atom distribution over the hydrogels is studied. The prepared systems are found to be promising for the further development of drug formulations.</p>","PeriodicalId":762,"journal":{"name":"Russian Journal of Inorganic Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Functional Design of Peroral Iron Compound Delivery Systems Based on Polymethylsilsesquioxane Hydrogels for the Therapy of Iron Deficiency Anemia\",\"authors\":\"P. D. Orlova, I. B. Meshkov, E. V. Latipov, S. G. Vasil’ev, A. A. Kalinina, A. M. Muzafarov, I. M. Le-Deygen\",\"doi\":\"10.1134/s0036023624600266\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Abstract</h3><p>An approach to the development of peroral iron drug delivery systems for the therapy of iron deficiency anemia is proposed. The new systems are based on polymethylsilsesquioxane hydrogels with a variable structure as biocompatible and biodegradable supports. The hydrogels are found to exhibit a high sorption capacity toward a saturated solution of FeCl<sub>3</sub>∙6H<sub>2</sub>O (0.27 M), whereas the sorption capacity toward a saturated solution of iron D-gluconate (0.24 M) is lower and amounts to ~30%. The developed delivery systems are studied by IR and UV spectroscopy, and the iron atom distribution over the hydrogels is studied. The prepared systems are found to be promising for the further development of drug formulations.</p>\",\"PeriodicalId\":762,\"journal\":{\"name\":\"Russian Journal of Inorganic Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of Inorganic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1134/s0036023624600266\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Inorganic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1134/s0036023624600266","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Functional Design of Peroral Iron Compound Delivery Systems Based on Polymethylsilsesquioxane Hydrogels for the Therapy of Iron Deficiency Anemia
Abstract
An approach to the development of peroral iron drug delivery systems for the therapy of iron deficiency anemia is proposed. The new systems are based on polymethylsilsesquioxane hydrogels with a variable structure as biocompatible and biodegradable supports. The hydrogels are found to exhibit a high sorption capacity toward a saturated solution of FeCl3∙6H2O (0.27 M), whereas the sorption capacity toward a saturated solution of iron D-gluconate (0.24 M) is lower and amounts to ~30%. The developed delivery systems are studied by IR and UV spectroscopy, and the iron atom distribution over the hydrogels is studied. The prepared systems are found to be promising for the further development of drug formulations.
期刊介绍:
Russian Journal of Inorganic Chemistry is a monthly periodical that covers the following topics of research: the synthesis and properties of inorganic compounds, coordination compounds, physicochemical analysis of inorganic systems, theoretical inorganic chemistry, physical methods of investigation, chemistry of solutions, inorganic materials, and nanomaterials.