小圆锥体可预测药物的体外毒性

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-08-01 DOI:10.1016/j.stem.2024.06.013

引用次数: 0

摘要

Mitrofanova 等人1 设计了一种能够产生肠粘液屏障的人体结肠体外模型，该模型可用于预测药物引起的胃肠道毒性。这一改进的系统为更准确、更高效的药物开发过程铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mini-colons predict drug toxicity in vitro

Mitrofanova et al.¹ engineer a human colonic in vitro model capable of producing an intestinal mucus barrier, with potential applications for predicting drug-induced gastrointestinal toxicity. This improved system paves the way for more accurate and efficient drug development processes.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.