工程血管移植物为了解主动脉瘤的病理生理学提供了独特视角

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-08-01 DOI:10.1016/j.stem.2024.07.002

引用次数: 0

摘要

Yang等人1利用携带Loeys-Dietz综合征突变的hiPSC衍生平滑肌细胞生成组织工程血管。这些血管的体外和体内数据为了解主动脉瘤的分子生理学提供了新的视角，并可能为了解一系列血管疾病提供范例。

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Engineered vascular grafts lend unique insight to pathophysiology of aortic aneurysms

Yang et al.¹ generate tissue engineered blood vessels from hiPSC-derived smooth muscle cells harboring a mutation found in Loeys-Dietz syndrome. In vitro and in vivo data from these vessels provide new insight into the molecular physiology of aortic aneurysms and may create a paradigm for understanding a suite of vascular diseases.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.