通过胎粪生物标志物获得产前饮酒的国际流行率:系统性文献综述。

IF 3 Q2 SUBSTANCE ABUSE
Orlagh Keating, Ruth H. Brown, Renate Kuenssberg, Sarah Driscoll, Stewart McDougall, Suzanne O'Rourke
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引用次数: 0

摘要

胎儿酒精暴露是一个日益受到关注的公共健康问题。然而,由于孕产妇的自我报告可能缺乏有效性,因此确定其真实程度仍具有挑战性。越来越多的人开始关注更客观的产前酒精使用(PAU)测量方法,其中胎粪被认为是一种有价值的工具。本综述评估了在普通孕产妇人群中使用胎粪生物标志物获得的 PAU 国际流行率,并在可行的情况下评估了胎粪生物标志物与自我报告的 PAU 之间的一致程度。从 1990 年到 2023 年,我们使用多个电子数据库对通过胎粪生物标记物检测确定的 PAU 患病率的研究进行了系统性文献检索。最终确定了 17 项研究可供纳入,并对研究方法的质量进行了评估。使用脂肪酸乙酯(FAEEs)胎粪生物标记物,PAU 患病率从 2.4% 到 44% 不等。基于EtG(乙基葡萄糖醛酸)分析的发病率从0%到16.3%不等,基于EtS(乙基硫酸酯)分析的发病率从7.8%到16.7%不等。研究质量中等,异质性较高。基于自我报告数据的患病率从 0% 到 46.4% 不等。当报告时,所审查的研究均未发现基于胎粪和基于自我报告的 PAU 患病率之间存在一致性。同时使用自我报告和胎粪生物标志物来检测妊娠早期的饮酒情况和妊娠晚期的饮酒情况,可以更全面地反映 PAU 的患病率。此外,还需要就该领域所需的确定、存储、分析和报告制定严格的指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The international prevalence of prenatal alcohol use obtained via meconium biomarkers: A systematic literature review

The international prevalence of prenatal alcohol use obtained via meconium biomarkers: A systematic literature review

The international prevalence of prenatal alcohol use obtained via meconium biomarkers: A systematic literature review

Fetal alcohol exposure is a growing public health concern. However, ascertaining its true extent remains challenging as maternal self-reports may lack validity. Increasingly, interest has turned to more objective measures of prenatal alcohol use (PAU) of which one, meconium, is recognized as a valuable tool. This review assesses both the international prevalence of PAU obtained using meconium biomarkers in general maternity populations and, when feasible, the level of agreement between meconium biomarkers and self-reported PAU. A systematic literature search for studies reporting the prevalence of PAU, as determined by meconium biomarker testing, was conducted using multiple electronic databases from 1990 to 2023. Seventeen studies were identified for inclusion and evaluated for methodological quality. Using fatty acid ethyl esters (FAEEs) meconium biomarkers, PAU prevalence varied from 2.4% to 44%. Rates based on EtG (ethyl glucuronide) analysis ranged from 0% to 16.3%, and EtS (ethyl sulfate) analysis from 7.8% to 16.7%. Studies were of moderate quality with high heterogeneity. Prevalence rates based on self-report data ranged from 0% to 46.4%. When reported, none of the reviewed studies identified agreement between meconium-based and self-report-based PAU prevalence rates. Using both self-reports to detect early pregnancy alcohol use, and meconium biomarkers to detect the occurrence of alcohol use later in pregnancy, may provide a more complete picture of PAU prevalence. Furthermore, research is warranted to develop stringent guidance on the ascertainment, storage, analysis, and reporting required in this field.

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