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引用次数: 0
摘要
背景：鼻窦未分化癌（SNUC）是一种罕见的侵袭性疾病，治疗不明确，预后差。本研究旨在评估放射治疗（RT）的作用，并探索最佳治疗顺序：方法：对1973年至2015年间410例SNUC患者的生存趋势进行回顾性分析：结果：在84个月的中位随访中，5年癌症特异性生存率（CSS）为45.1%，总生存率（OS）为38.1%。放疗是改善 CSS 的预后指标（危险比 [HR] = 0.425，95% 置信区间 [CI]：0.299-0.603）：0.299-0.603, p = 0.000）和OS（HR = 0.415, 95% CI: 0.303-0.570, p = 0.000）。然而，在手术和 RT 的联合治疗中，术前和术后 RT（5 年 OS 率分别为 47.1% 和 45.6%，p = 0.486）没有显著差异：结论：放疗在提高SNUC生存率方面发挥着关键作用。结论：放疗在提高SNUC生存率方面发挥着关键作用，术前和术后RT治疗在生存率方面无明显差异。
The role of radiotherapy in the treatment of sinonasal undifferentiated carcinoma: A population-based analysis.
Background: Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive disease with ambiguous management and poor prognosis. This study aimed to evaluate the role of radiation therapy (RT) and explore the optimal treatment sequence.
Methods: Retrospective analysis of survival trends of 410 SNUC patients between 1973 and 2015.
Results: The 5-year cancer-specific survival (CSS) rate (45.1%) and overall survival (OS) rates (38.1%) were reported in the 84-month median follow-up. Radiotherapy was a prognosticator for improving CSS (hazard ratio [HR] = 0.425, 95% confidence interval [CI]: 0.299-0.603, p = 0.000) and OS (HR = 0.415, 95% CI: 0.303-0.570, p = 0.000), either with surgery (p = 0.000) or without surgery (p = 0.000). However, in a combined therapy of surgery and RT, preoperative and postoperative RT (5-year OS rates were 47.1% and 45.6%, respectively, p = 0.486) were not significantly different.
Conclusions: Radiotherapy plays a key role in improving SNUC survival rates. No significant difference in survival rates was observed in preoperative and postoperative RT treatment.
期刊介绍：
Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.
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