Alexander C Egbe, William R Miranda, C Charles Jain, Heidi M Connolly
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引用次数: 0
摘要
研究目的主动脉共动脉症(COA)患者的动脉僵化和左心室舒张功能障碍与射血分数保留型心力衰竭(HFpEF)患者和肥胖者相似。然而,成人 COA 患者的肥胖、心脏血液动力学和高血压之间的关系尚不清楚。本研究的目的是比较有肥胖症与无肥胖症的 COA 患者的心脏血流动力学和 HFpEF 患病率,并评估肥胖与 HFpEF 在该人群中的关系:方法:将接受右心导管检查的 COA 患者分为肥胖组(体重指数大于 30 kg/m2)和非肥胖组(体重指数小于 30 kg/m2)。我们还选择了一组无结构性心脏病且静息时有创血流动力学正常的受试者作为对照组(36 人)。HFpEF的定义是具有HF临床症状(劳累性呼吸困难或疲劳)、左心室射血分数至少为50%、静息时肺动脉楔压(PAWP)大于15毫米汞柱:99名COA患者中,29人(29%)患有肥胖症。与非肥胖 COA 组和对照组相比,肥胖 COA 组的右心房压力和 PAWP 较高,肺和全身血管功能较差。成人 COA 患者中 HFpEF 的总患病率为 32%,与非肥胖患者(23%)相比,肥胖 COA 患者的患病率更高(55%)。在对人口统计学指数、合并症和血管功能进行调整后,肥胖与HFpEF相关:结论:肥胖症 COA 患者的血液动力学异常和较高的 HFpEF 患病率凸显了对肥胖症人群进行干预的必要性。
期刊介绍:
The Journal of Invasive Cardiology will consider for publication suitable articles on topics pertaining to the invasive treatment of patients with cardiovascular disease.