希腊北部成年人的维生素 D 结合蛋白 (DBP)、游离钙二醇和总钙三醇。

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Constantine Anetakis, Stella Mitka, Maria Hadjidimitriou, Konstantinos Anagnostopoulos, Theodoros Lialiaris
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引用次数: 0

摘要

背景:关于在人群中使用总钙化二醇还是游离钙化二醇作为筛查试验更好的问题一直存在争议:在冬季和夏季,通过免疫酶法测定了326名成年人(161名男性,165名女性)体内游离降钙二醇、总降钙素三醇和维生素D结合蛋白(DBP)的浓度。其中包括 99 名骨质疏松症患者、53 名 1 型糖尿病患者和 51 名 2 型糖尿病患者,以及 123 名健康运动员,他们都来自希腊北部:在所有样本中,男性(5.53 pg/ml)和女性(4.68 pg/ml)的游离钙化二醇平均浓度差异显著(p < 0.001)。运动健康组(6.02 pg/ml)的游离钙化二醇含量明显高于三个患者组,而骨质疏松症组的游离钙化二醇含量最低(3.69 pg/ml)。除 2 型糖尿病患者(男性 38.33 pg/ml,女性 54.52 pg/ml,p = 0.001)外,总钙三醇平均浓度在整个样本(p = 0.896)或研究组中的性别差异不大。骨质疏松症患者(34.61 pg/ml)明显低于运动健康组(41.65 pg/ml,p = 0.037)和 1 型糖尿病患者(43.73 pg/ml,p = 0.030),而其他研究组之间没有明显差异。DBP的平均浓度在整个样本和研究组的性别之间以及研究组之间均无明显差异(p = 0.467):与我们之前报告的总钙化二醇结果相比,游离钙化二醇的测量结果仅此而已,总钙三醇并不是评估维生素 D 状态的灵敏指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vitamin D Binding Protein (DBP), Free Calcidiol, and Total Calcitriol in Adults from Northern Greece.

Background: An ongoing debate has been raised on whether is better to use total or free calcidiol as a screening test in the population.

Methods: In winter and summer, free calcidiol, total calcitriol, and vitamin D binding protein (DBP) concentrations were determined by immunoenzymatic assays in 326 adults (161 males, 165 females). These included 99 osteoporotic patients, 53 type 1 and 51 type 2 diabetics, and 123 athletic healthy persons, all from northern Greece.

Results: In the whole sample, free calcidiol mean concentrations differed significantly (p < 0.001) between males (5.53 pg/ml) and females (4.68 pg/ml). Free calcidiol was significantly greater in the athletic healthy group (6.02 pg/ml) than in the three patient groups, and lowest in the osteoporosis group (3.69 pg/ml). Total calcitriol mean concentration did not differ significantly between genders in the whole sample (p = 0.896) or in the study groups, except for type 2 diabetics (males 38.33 pg/ml, females 54.52 pg/ml, p = 0.001). It was significantly less in the osteoporotics (34.61 pg/ml) than in the athletic healthy group (41.65 pg/ml, p = 0.037) and type 1 diabetics (43.73 pg/ml, p = 0.030), whereas it did not differ significantly between the other study groups. The DBP mean concentrations were not significantly different between genders in the whole sample and the study groups nor among the study groups (p = 0.467).

Conclusion: Comparisons with our previously reported results of total calcidiol suggest the measurement of free calcidiol offers nothing more than that, and total calcitriol is not a sensitive measure for assessing vitamin D status.

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来源期刊
Reports of Biochemistry and Molecular Biology
Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
2.80
自引率
23.50%
发文量
60
审稿时长
10 weeks
期刊介绍: The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.
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