Flávia E Jacinto, Letícia Pires de Oliveira, Alzir A Batista, Katia M Oliveira, Rodrigo S Correa
{"title":"姜黄素和β-二酮衍生物的钌(II)配合物:结构修饰对其细胞毒性的影响。","authors":"Flávia E Jacinto, Letícia Pires de Oliveira, Alzir A Batista, Katia M Oliveira, Rodrigo S Correa","doi":"10.1098/rsos.240353","DOIUrl":null,"url":null,"abstract":"<p><p>Ruthenium(II) complexes (<b>Ru1</b>-<b>Ru3</b>) with the general formula [Ru(O-O)(PPh<sub>3</sub>)<sub>2</sub>(bipy)]PF<sub>6,</sub> bearing two triphenylphosphine (PPh<sub>3</sub>), bipyridine (bipy) and a series of natural and synthetic β-diketones (O,O) ligands were synthesized and characterized using various analytical techniques. The interaction between the complexes and <i>calf thymus</i> DNA (CT-DNA) was investigated and demonstrated a weak interaction. The cytotoxicity of the complexes was investigated against breast cancer cells (MDA-MB-231 and MCF-7), lung cancer cells (A549), cisplatin-resistant ovarian cancer cells (A2780<i>cis</i>), as well as non-tumour lung (MRC-5) and non-tumour breast (MCF-10A) cell lines. All complexes exhibited cytotoxic activity against all the cell lines studied, with half maximal inhibitory concentration (IC<sub>50</sub>) values ranging from 0.39 to 13 µM. Notably, the three complexes demonstrated selectivity against the A2780<i>cis</i> cell line, with IC<sub>50</sub> ranging from 0.39 to 0.82 µM. Among them, Ru2 exhibited the highest cytotoxicity, with an IC<sub>50</sub> value of 0.39 µM. Consequently, this new class of complexes shows good selectivity towards cisplatin-resistant ovarian cancer cells and it is promising for further investigation as anti-cancer agents.</p>","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11289651/pdf/","citationCount":"0","resultStr":"{\"title\":\"Ruthenium(II) complexes of curcumin and β-diketone derivatives: effect of structural modifications on their cytotoxicity.\",\"authors\":\"Flávia E Jacinto, Letícia Pires de Oliveira, Alzir A Batista, Katia M Oliveira, Rodrigo S Correa\",\"doi\":\"10.1098/rsos.240353\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Ruthenium(II) complexes (<b>Ru1</b>-<b>Ru3</b>) with the general formula [Ru(O-O)(PPh<sub>3</sub>)<sub>2</sub>(bipy)]PF<sub>6,</sub> bearing two triphenylphosphine (PPh<sub>3</sub>), bipyridine (bipy) and a series of natural and synthetic β-diketones (O,O) ligands were synthesized and characterized using various analytical techniques. The interaction between the complexes and <i>calf thymus</i> DNA (CT-DNA) was investigated and demonstrated a weak interaction. The cytotoxicity of the complexes was investigated against breast cancer cells (MDA-MB-231 and MCF-7), lung cancer cells (A549), cisplatin-resistant ovarian cancer cells (A2780<i>cis</i>), as well as non-tumour lung (MRC-5) and non-tumour breast (MCF-10A) cell lines. All complexes exhibited cytotoxic activity against all the cell lines studied, with half maximal inhibitory concentration (IC<sub>50</sub>) values ranging from 0.39 to 13 µM. Notably, the three complexes demonstrated selectivity against the A2780<i>cis</i> cell line, with IC<sub>50</sub> ranging from 0.39 to 0.82 µM. Among them, Ru2 exhibited the highest cytotoxicity, with an IC<sub>50</sub> value of 0.39 µM. Consequently, this new class of complexes shows good selectivity towards cisplatin-resistant ovarian cancer cells and it is promising for further investigation as anti-cancer agents.</p>\",\"PeriodicalId\":21525,\"journal\":{\"name\":\"Royal Society Open Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11289651/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Royal Society Open Science\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.1098/rsos.240353\",\"RegionNum\":3,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Royal Society Open Science","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1098/rsos.240353","RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
Ruthenium(II) complexes of curcumin and β-diketone derivatives: effect of structural modifications on their cytotoxicity.
Ruthenium(II) complexes (Ru1-Ru3) with the general formula [Ru(O-O)(PPh3)2(bipy)]PF6, bearing two triphenylphosphine (PPh3), bipyridine (bipy) and a series of natural and synthetic β-diketones (O,O) ligands were synthesized and characterized using various analytical techniques. The interaction between the complexes and calf thymus DNA (CT-DNA) was investigated and demonstrated a weak interaction. The cytotoxicity of the complexes was investigated against breast cancer cells (MDA-MB-231 and MCF-7), lung cancer cells (A549), cisplatin-resistant ovarian cancer cells (A2780cis), as well as non-tumour lung (MRC-5) and non-tumour breast (MCF-10A) cell lines. All complexes exhibited cytotoxic activity against all the cell lines studied, with half maximal inhibitory concentration (IC50) values ranging from 0.39 to 13 µM. Notably, the three complexes demonstrated selectivity against the A2780cis cell line, with IC50 ranging from 0.39 to 0.82 µM. Among them, Ru2 exhibited the highest cytotoxicity, with an IC50 value of 0.39 µM. Consequently, this new class of complexes shows good selectivity towards cisplatin-resistant ovarian cancer cells and it is promising for further investigation as anti-cancer agents.
期刊介绍:
Royal Society Open Science is a new open journal publishing high-quality original research across the entire range of science on the basis of objective peer-review.
The journal covers the entire range of science and mathematics and will allow the Society to publish all the high-quality work it receives without the usual restrictions on scope, length or impact.