Federica Serafini, Kristen M. Maxwell, Xiaojuan Zhu, Elizabeth M. Lennon
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In veterinary species, decreased concentrations of vitamin D are relatively common in dogs with chronic enteropathy (CE), but data on the status of other fat-soluble vitamins (FSVs) is lacking.</p>\n </section>\n \n <section>\n \n <h3> Objectives</h3>\n \n <p>Determine the serum concentrations of retinol, vitamin D, and α-tocopherol in dogs with CE compared with healthy dogs and compare clinical, clinicopathologic variables between CE and healthy dogs to detect associations with decreased FSVs concentrations.</p>\n </section>\n \n <section>\n \n <h3> Animals</h3>\n \n <p>Eighteen client-owned dogs with CE and 33 healthy dogs.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Serum 25-hydroxyvitamin D (25[OH]D), serum retinol and α-tocopherol concentrations were compared between groups. Correlations and multiple regression modeling were used to examine the relationship between serum 25(OH)D, retinol, and α-tocopherol concentrations and clinical and clinicopathological variables.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Dogs with low serum albumin concentrations were more likely to have lower 25(OH)D concentrations than dogs with normal serum albumin concentration. Dogs with CE had higher serum concentrations of retinol, and variable α-tocopherol concentrations. The cause of these dysregulated vitamin concentrations is unclear and requires further study.</p>\n </section>\n \n <section>\n \n <h3> Conclusion and Clinical Importance</h3>\n \n <p>Dogs with severe forms of CE should be monitored for decreased concentrations of 25(OH)D. Additional studies are needed to evaluate the clinical relevance and the possible benefit of vitamin D supplementation in these patients.</p>\n </section>\n </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17107","citationCount":"0","resultStr":"{\"title\":\"Dysregulated serum concentrations of fat-soluble vitamins in dogs with chronic enteropathy\",\"authors\":\"Federica Serafini, Kristen M. Maxwell, Xiaojuan Zhu, Elizabeth M. Lennon\",\"doi\":\"10.1111/jvim.17107\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>In inflammatory bowel disease (IBD) of humans, nutrient malabsorption can result in fat-soluble vitamin deficiency, especially of vitamin D. 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Correlations and multiple regression modeling were used to examine the relationship between serum 25(OH)D, retinol, and α-tocopherol concentrations and clinical and clinicopathological variables.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Dogs with low serum albumin concentrations were more likely to have lower 25(OH)D concentrations than dogs with normal serum albumin concentration. Dogs with CE had higher serum concentrations of retinol, and variable α-tocopherol concentrations. The cause of these dysregulated vitamin concentrations is unclear and requires further study.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion and Clinical Importance</h3>\\n \\n <p>Dogs with severe forms of CE should be monitored for decreased concentrations of 25(OH)D. 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引用次数: 0
摘要
背景:在兽医物种中,慢性肠病(CE)犬的维生素 D 浓度降低比较常见,但缺乏有关其他脂溶性维生素(FSV)状况的数据:目标:与健康犬相比,确定患有慢性肠病的犬血清中视黄醇、维生素 D 和 α-生育酚的浓度,并比较患有慢性肠病的犬和健康犬的临床和临床病理变量,以检测与脂溶性维生素浓度降低的关系:动物:18 只患有 CE 的客户饲养犬和 33 只健康犬:方法:比较不同组间的血清 25- 羟维生素 D (25[OH]D)、血清视黄醇和 α-生育酚浓度。使用相关性和多元回归模型研究血清 25(OH)D、视黄醇和 α-生育酚浓度与临床和临床病理学变量之间的关系:结果:与血清白蛋白浓度正常的狗相比,血清白蛋白浓度低的狗的 25(OH)D 浓度更低。患有 CE 的犬血清中视黄醇浓度较高,而 α-生育酚浓度则不尽相同。这些维生素浓度失调的原因尚不清楚,需要进一步研究:结论和临床意义:应监测患有严重CE的犬只体内25(OH)D浓度是否降低。需要进行更多的研究,以评估维生素 D 补充剂对这些患者的临床意义和可能的益处。
Dysregulated serum concentrations of fat-soluble vitamins in dogs with chronic enteropathy
Background
In inflammatory bowel disease (IBD) of humans, nutrient malabsorption can result in fat-soluble vitamin deficiency, especially of vitamin D. In veterinary species, decreased concentrations of vitamin D are relatively common in dogs with chronic enteropathy (CE), but data on the status of other fat-soluble vitamins (FSVs) is lacking.
Objectives
Determine the serum concentrations of retinol, vitamin D, and α-tocopherol in dogs with CE compared with healthy dogs and compare clinical, clinicopathologic variables between CE and healthy dogs to detect associations with decreased FSVs concentrations.
Animals
Eighteen client-owned dogs with CE and 33 healthy dogs.
Methods
Serum 25-hydroxyvitamin D (25[OH]D), serum retinol and α-tocopherol concentrations were compared between groups. Correlations and multiple regression modeling were used to examine the relationship between serum 25(OH)D, retinol, and α-tocopherol concentrations and clinical and clinicopathological variables.
Results
Dogs with low serum albumin concentrations were more likely to have lower 25(OH)D concentrations than dogs with normal serum albumin concentration. Dogs with CE had higher serum concentrations of retinol, and variable α-tocopherol concentrations. The cause of these dysregulated vitamin concentrations is unclear and requires further study.
Conclusion and Clinical Importance
Dogs with severe forms of CE should be monitored for decreased concentrations of 25(OH)D. Additional studies are needed to evaluate the clinical relevance and the possible benefit of vitamin D supplementation in these patients.
期刊介绍:
The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.