24R005A 和 24R005B：从鱼粉培养基中培养的链霉菌中获得的新型 DPPH 自由基清除剂。

IF 0.8 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of General and Applied Microbiology Pub Date : 2024-07-31 DOI:10.2323/jgam.2024.07.002

Toshikazu Komoda, Mayu Abe, Yoshitaka Koseki

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引用次数: 0

摘要

我们以鱼（鯷鱼）粉为培养基，成功地从链霉菌 24R005 中分离出两种新型化合物 24R005A（1，C13H14O4）和 24R005B（2，C13H13ClO4）。在这项研究中，我们评估了使用鱼（凤尾鱼）粉作为发酵材料生产生物活性化合物的情况。光谱分析显示，这两种化合物具有共同的骨架结构。不过，每种化合物都含有独特的支链侧链。此外，化合物 1 和 2 对 1,1-二苯基-2-苦基肼（DPPH）具有中等程度的自由基清除活性，ED50 值分别为 200 和 130 μM。

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24R005A and 24R005B: Novel radical scavengers of DPPH obtained from Streptomyces sp. cultured in a fish powder medium.

We have successfully isolated two novel compounds, 24R005A (1, C₁₃H₁₄O₄) and 24R005B (2, C₁₃H₁₃ClO₄), from Streptomyces sp. 24R005, using fish (anchovy) powder as a medium. In this study, we evaluated the use of fish (anchovy) powder as a fermentation material for producing bioactive compounds. Spectroscopic analyses revealed that the two compounds share a common skeletal structure. However, each compound contains unique branched side chains. Furthermore, compounds 1 and 2 exhibit moderate radical-scavenging activity for 1,1-diphenyl-2-picrylhydrazyl (DPPH), with ED₅₀ values of 200 and 130 μM, respectively.

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来源期刊

Journal of General and Applied Microbiology 生物-生物工程与应用微生物

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： JGAM is going to publish scientific reports containing novel and significant microbiological findings, which are mainly devoted to the following categories: Antibiotics and Secondary Metabolites; Biotechnology and Metabolic Engineering; Developmental Microbiology; Environmental Microbiology and Bioremediation; Enzymology; Eukaryotic Microbiology; Evolution and Phylogenetics; Genome Integrity and Plasticity; Microalgae and Photosynthesis; Microbiology for Food; Molecular Genetics; Physiology and Cell Surface; Synthetic and Systems Microbiology.