在诊断假体周围关节感染方面,血清白蛋白与球蛋白的比率和 CRP 与白蛋白的比率并不优于血清 CRP。

IF 4.7 2区 医学 Q2 CELL & TISSUE ENGINEERING
Markus Luger, Christoph Böhler, Stephan E Puchner, Sebastian Apprich, Kevin Staats, Reinhard Windhager, Irene K Sigmund
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引用次数: 0

摘要

目的:血清炎症参数被广泛用于辅助诊断假体周围关节感染(PJI)。由于这些指标在文献中的表现有限,因此需要新的、更准确的生物标志物。血清白蛋白与球蛋白比值(AGR)和血清 CRP 与白蛋白比值(CAR)曾被提议作为潜在的新参数,但结果不一。本研究旨在评估 AGR 和 CAR 诊断 PJI 的准确性,并将其与已被广泛使用的标志物 CRP 进行比较:这项回顾性队列研究纳入了 2015 年至 2022 年连续 275 例翻修全髋关节(129 例)和膝关节(146 例)的病例。根据 2021 年欧洲骨与关节感染学会(EBJIS)的定义,144 例关节置换术被归类为败血症。通过接收器操作特征曲线(ROC)分析,计算出了理想的阈值和诊断性能。结果显示,AGR、CAR和CRP均高于CRP:结果:AGR、CAR 和 CRP 与 PJI 相关(p < 0.001)。灵敏度分别为 62.5%(95% CI 54.3 至 70.0)、73.6%(95% CI 65.8 至 80.1)和 71.5%(95% CI 63.6 至 78.3)。特异性分别为 84.7%(95% CI 77.5 至 89.9)、86.3%(95% CI 79.2 至 91.2)和 87.8%(95% CI 80.9 至 92.4)。CRP 的 AUC(0.797(95% CI 0.750 至 0.843))明显高于 AGR 的 AUC(0.736(95% CI 0.686 至 0.786),p < 0.001),与 CAR 的 AUC(0.799(95% CI 0.753 至 0.846),p = 0.832)相似。与高致病性病原体(AGR:80%,p = 0.042;CAR:88%,p = 0.158)相比,低致病性病原体(AGR:60%,CAR:78%)引起的 PJI 的敏感性降低。急性血源性(AGR:83%,CAR:96%)与慢性肺结核(AGR:54%,p = 0.001;CAR:65%,p < 0.001)相比,敏感性更高:结论:在我们的研究中,血清 AGR 和 CAR 显示出有限的诊断准确性(尤其是在低级别和慢性感染中),并不优于已确定的标志物 CRP。因此,建议将这两个参数作为诊断 PJI 的额外工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum albumin-to-globulin ratio and CRP-to-albumin ratio did not outperform serum CRP in diagnosing periprosthetic joint infections.

Aims: Serum inflammatory parameters are widely used to aid in diagnosing a periprosthetic joint infection (PJI). Due to their limited performances in the literature, novel and more accurate biomarkers are needed. Serum albumin-to-globulin ratio (AGR) and serum CRP-to-albumin ratio (CAR) have previously been proposed as potential new parameters, but results were mixed. The aim of this study was to assess the diagnostic accuracy of AGR and CAR in diagnosing PJI and to compare them to the established and widely used marker CRP.

Methods: From 2015 to 2022, a consecutive series of 275 cases of revision total hip (n = 129) and knee arthroplasty (n = 146) were included in this retrospective cohort study. Based on the 2021 European Bone and Joint Infection Society (EBJIS) definition, 144 arthroplasties were classified as septic. Using receiver operating characteristic curve (ROC) analysis, the ideal thresholds and diagnostic performances were calculated. The areas under the curve (AUCs) were compared using the z-test.

Results: AGR, CAR, and CRP were associated with PJI (p < 0.001). Sensitivities were 62.5% (95% CI 54.3 to 70.0), 73.6% (95% CI 65.8 to 80.1), and 71.5% (95% CI 63.6 to 78.3), respectively. Specificities were calculated with 84.7% (95% CI 77.5 to 89.9), 86.3% (95% CI 79.2 to 91.2), and 87.8% (95% CI 80.9 to 92.4), respectively. The AUC of CRP (0.797 (95% CI 0.750 to 0.843)) was significantly higher than the AUC of AGR (0.736 (95% CI 0.686 to 0.786), p < 0.001), and similar to AUC of CAR (0.799 (95% CI 0.753 to 0.846), p = 0.832). Decreased sensitivities were observed in PJIs caused by low-virulence organisms (AGR: 60%, CAR: 78%) compared to high-virulence pathogens (AGR: 80%, p = 0.042; CAR: 88%, p = 0.158). Higher sensitivities were seen in acute haematogenous (AGR: 83%, CAR: 96%) compared to chronic PJIs (AGR: 54%, p = 0.001; CAR: 65%, p < 0.001).

Conclusion: Serum AGR and CAR showed limited diagnostic accuracy (especially in low-grade and chronic infections) and did not outperform the established marker CRP in our study. Hence, neither parameter can be recommended as an additional tool for diagnosing PJI.

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来源期刊
Bone & Joint Research
Bone & Joint Research CELL & TISSUE ENGINEERING-ORTHOPEDICS
CiteScore
7.40
自引率
23.90%
发文量
156
审稿时长
12 weeks
期刊介绍: The gold open access journal for the musculoskeletal sciences. Included in PubMed and available in PubMed Central.
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