Sonal Gahlawat, Doga Oruc, Nikhil Paul, Mark Ragheb, Swati Patel, Oyinkansola Fasasi, Peeyush Sharma, David I. Shreiber, Joseph W. Freeman
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引用次数: 0
摘要
骨骼肌的严重损伤,包括体积性肌肉缺失(VML),与大量组织损伤有关,导致功能障碍和持久残疾。虽然骨骼肌在受到轻微损伤后可以再生,但体积性肌肉缺失(VML)造成的大面积组织缺失会破坏受影响肌肉组织的自然再生能力。治疗 VML 的现有临床方法,如软组织重建和先进的支具方法,需要进行修改以恢复组织功能,并且存在组织可用性和供体部位并发症的限制。组织工程(TE)的进步,尤其是在支架设计和细胞与生长因子的输送方面,显示出再生受损骨骼肌组织和恢复功能的巨大潜力。本文简要概述了 VML 的病理生理学,并批评了当前治疗方法的不足之处。随后的章节重点讨论了 TE 支架的设计标准,深入探讨了有效再生骨骼肌的各种天然和合成生物材料及细胞类型。我们还回顾了涉及无细胞支架和细胞支架的多种 TE 策略,以促进肌肉组织的发育和成熟,并促进整合、血管化和神经支配。最后,文章探讨了阻碍成功转化为临床应用的技术挑战。
Tissue Engineered 3D Constructs for Volumetric Muscle Loss
Severe injuries to skeletal muscles, including cases of volumetric muscle loss (VML), are linked to substantial tissue damage, resulting in functional impairment and lasting disability. While skeletal muscle can regenerate following minor damage, extensive tissue loss in VML disrupts the natural regenerative capacity of the affected muscle tissue. Existing clinical approaches for VML, such as soft-tissue reconstruction and advanced bracing methods, need to be revised to restore tissue function and are associated with limitations in tissue availability and donor-site complications. Advancements in tissue engineering (TE), particularly in scaffold design and the delivery of cells and growth factors, show promising potential for regenerating damaged skeletal muscle tissue and restoring function. This article provides a brief overview of the pathophysiology of VML and critiques the shortcomings of current treatments. The subsequent section focuses on the criteria for designing TE scaffolds, offering insights into various natural and synthetic biomaterials and cell types for effectively regenerating skeletal muscle. We also review multiple TE strategies involving both acellular and cellular scaffolds to encourage the development and maturation of muscle tissue and facilitate integration, vascularization, and innervation. Finally, the article explores technical challenges hindering successful translation into clinical applications.
期刊介绍:
Annals of Biomedical Engineering is an official journal of the Biomedical Engineering Society, publishing original articles in the major fields of bioengineering and biomedical engineering. The Annals is an interdisciplinary and international journal with the aim to highlight integrated approaches to the solutions of biological and biomedical problems.