Jose J. Gil-Cosano, Abel Plaza-Florido, Luis Gracia-Marco, Jairo H. Migueles, Cristina Cadenas-Sanchez, Marcos Olvera-Rojas, Esther Ubago-Guisado, Idoia Labayen, Alejandro Lucia, Francisco B. Ortega
{"title":"有氧训练和阻力训练相结合对超重/肥胖儿童炎症特征的影响：随机临床试验","authors":"Jose J. Gil-Cosano, Abel Plaza-Florido, Luis Gracia-Marco, Jairo H. Migueles, Cristina Cadenas-Sanchez, Marcos Olvera-Rojas, Esther Ubago-Guisado, Idoia Labayen, Alejandro Lucia, Francisco B. Ortega","doi":"10.1111/ijpo.13152","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>We assessed the effects of a 20-week combined (aerobic and resistance) exercise training programme on the inflammatory profile of prepubertal children with overweight or obesity.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Totally 109 participants (10.1 ± 1.1 years, 41% girls) were randomly allocated to an exercise or control group. Adiponectin, C-reactive protein, epidermal growth factor, insulin-like growth factor-1, interleukin (IL)-1β, IL-6, leptin, tumour necrosis factor-α and vascular endothelial growth factor A (VEGFA) were analysed in plasma. Total white blood cell (WBC) count and immune subpopulations (eosinophils, basophils, neutrophils, lymphocytes and monocytes) were also determined.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>No intervention effect was found for any of the analysed biomarkers (all <i>p</i> ≥ 0.05). We observed a significant sex by intervention interaction for IL-1β (<i>p</i> = 0.03). When stratifying the sample by sex, the exercise programme induced a significant effect on IL-1β levels (mean <i>Z</i>-score difference, 0.66 [95% confidence interval 0.32–1.01]) in girls, but not in boys. A lower number of girls in the exercise group showed a meaningful reduction in IL-1β (i.e., ≥0.2 standard deviations) than in the control group (15% vs. 85%, <i>p</i> = 0.01).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>This exercise programme failed to improve the inflammatory profile in prepubertal children with overweight/obesity. Future studies should explore the effect of longer exercise interventions and in combination with diet.</p>\n </section>\n </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"19 10","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.13152","citationCount":"0","resultStr":"{\"title\":\"Effects of combined aerobic and resistance training on the inflammatory profile of children with overweight/obesity: A randomized clinical trial\",\"authors\":\"Jose J. Gil-Cosano, Abel Plaza-Florido, Luis Gracia-Marco, Jairo H. Migueles, Cristina Cadenas-Sanchez, Marcos Olvera-Rojas, Esther Ubago-Guisado, Idoia Labayen, Alejandro Lucia, Francisco B. Ortega\",\"doi\":\"10.1111/ijpo.13152\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>We assessed the effects of a 20-week combined (aerobic and resistance) exercise training programme on the inflammatory profile of prepubertal children with overweight or obesity.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Totally 109 participants (10.1 ± 1.1 years, 41% girls) were randomly allocated to an exercise or control group. Adiponectin, C-reactive protein, epidermal growth factor, insulin-like growth factor-1, interleukin (IL)-1β, IL-6, leptin, tumour necrosis factor-α and vascular endothelial growth factor A (VEGFA) were analysed in plasma. Total white blood cell (WBC) count and immune subpopulations (eosinophils, basophils, neutrophils, lymphocytes and monocytes) were also determined.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>No intervention effect was found for any of the analysed biomarkers (all <i>p</i> ≥ 0.05). We observed a significant sex by intervention interaction for IL-1β (<i>p</i> = 0.03). When stratifying the sample by sex, the exercise programme induced a significant effect on IL-1β levels (mean <i>Z</i>-score difference, 0.66 [95% confidence interval 0.32–1.01]) in girls, but not in boys. A lower number of girls in the exercise group showed a meaningful reduction in IL-1β (i.e., ≥0.2 standard deviations) than in the control group (15% vs. 85%, <i>p</i> = 0.01).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>This exercise programme failed to improve the inflammatory profile in prepubertal children with overweight/obesity. Future studies should explore the effect of longer exercise interventions and in combination with diet.</p>\\n </section>\\n </div>\",\"PeriodicalId\":217,\"journal\":{\"name\":\"Pediatric Obesity\",\"volume\":\"19 10\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.13152\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Obesity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/ijpo.13152\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ijpo.13152","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
Effects of combined aerobic and resistance training on the inflammatory profile of children with overweight/obesity: A randomized clinical trial
Background
We assessed the effects of a 20-week combined (aerobic and resistance) exercise training programme on the inflammatory profile of prepubertal children with overweight or obesity.
Methods
Totally 109 participants (10.1 ± 1.1 years, 41% girls) were randomly allocated to an exercise or control group. Adiponectin, C-reactive protein, epidermal growth factor, insulin-like growth factor-1, interleukin (IL)-1β, IL-6, leptin, tumour necrosis factor-α and vascular endothelial growth factor A (VEGFA) were analysed in plasma. Total white blood cell (WBC) count and immune subpopulations (eosinophils, basophils, neutrophils, lymphocytes and monocytes) were also determined.
Results
No intervention effect was found for any of the analysed biomarkers (all p ≥ 0.05). We observed a significant sex by intervention interaction for IL-1β (p = 0.03). When stratifying the sample by sex, the exercise programme induced a significant effect on IL-1β levels (mean Z-score difference, 0.66 [95% confidence interval 0.32–1.01]) in girls, but not in boys. A lower number of girls in the exercise group showed a meaningful reduction in IL-1β (i.e., ≥0.2 standard deviations) than in the control group (15% vs. 85%, p = 0.01).
Conclusions
This exercise programme failed to improve the inflammatory profile in prepubertal children with overweight/obesity. Future studies should explore the effect of longer exercise interventions and in combination with diet.
期刊介绍：
Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large.
Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following:
Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes
Metabolic consequences of child and adolescent obesity
Epidemiological and population-based studies of child and adolescent overweight and obesity
Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition
Clinical management of children and adolescents with obesity including studies of treatment and prevention
Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment
Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity
Nutrition security and the "double burden" of obesity and malnutrition
Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents
Community and public health measures to prevent overweight and obesity in children and adolescents.
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