焦磷酸钙沉积症（CPPD）不同炎症表型的相关特征：利用国际 ACR/EULAR CPPD 分类标准队列数据进行的研究。

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2024-08-01 DOI:10.1002/art.42962

Tristan Pascart, Augustin Latourte, Sara K Tedeschi, Nicola Dalbeth, Tuhina Neogi, Antonella Adinolfi, Uri Arad, Mariano Andres, Fabio Becce, Thomas Bardin, Edoardo Cipolletta, Hang-Korng Ea, Georgios Filippou, Emilio Filippucci, John FitzGerald, Annamaria Iagnocco, Tim L Jansen, Matthijs Janssen, Frédéric Lioté, Alexander So, Geraldine M McCarthy, Roberta Ramonda, Pascal Richette, Ann Rosenthal, Carlo Scirè, Ettore Silvagni, Silvia Sirotti, Francisca Sivera, Lisa K Stamp, William J Taylor, Robert Terkeltaub, Hyon K Choi, Abhishek Abhishek

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引用次数: 0

摘要

目的研究与焦磷酸钙沉积症（CPPD）不同炎症表型（即复发性急性CPP晶体关节炎、慢性CPP晶体炎症性关节炎和冠状窝综合征（CDS））相关的疾病、人口统计学和影像学特征：为制定和验证 2023 年 ACR/EULAR CPPD 分类标准，从 7 个国家的 25 个地点收集了符合标准的国际队列数据。研究人员进行了三项横断面研究，以确定复发性急性 CPP 晶体关节炎、慢性 CPP 晶体炎症性关节炎和 CDS 的表型特征。采用多变量逻辑回归分析计算调整后的几率比（aOR）和95%置信区间（CI），以研究潜在风险因素与炎症表型之间的关系：在纳入的 618 人中（56% 为女性），平均年龄（标准差（S.D.74.0 (11.9)岁）中，602 人（97.4%）曾患急性 CPP 晶体关节炎，332 人（53.7%）曾患复发性急性关节炎，158 人（25.6%）曾患持续性炎症性关节炎，45 人（7.3%）曾患 CDS。复发性急性 CPP 晶体关节炎与病程较长有关（aOR 2.88（95%CI 2.00;4.14））。急性腕关节炎（aOR(95%CI) 2.92(1.81-4.73)）、掌指关节炎（aOR(95%CI) 1.87(1.17-2.97)）和肩胛关节炎（aOR(95%CI) 2.92(1.81-4.73)）。97）和肩胛-腕-肘（STT）关节骨关节炎（aOR(95% CI) 1.83(1.15-2.91)），并与 CPPD 的代谢风险或家族风险呈负相关（aOR(95% CI) 0.60(0.37-0.96)）。CDS与男性性别（aOR(95% CI) 2.35(1.21-4.59)）、STT关节骨关节炎（aOR(95% CI) 2.71(1.22-6.05)）和更多关节受软骨钙化症影响（aOR(95% CI) 1.46(1.15-1.85)）有关：CPPD疾病包括急性和慢性炎症表型，每种表型都有特定的临床和影像学特征，需要在诊断工作中加以考虑。

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Features Associated With Different Inflammatory Phenotypes of Calcium Pyrophosphate Deposition Disease: Study Using Data From the International American College of Rheumatology/EULAR Calcium Pyrophosphate Deposition Classification Criteria Cohort.

Objective: The study objective was to examine the disease, demographic, and imaging features associated with different inflammatory phenotypes of calcium pyrophosphate deposition (CPPD) disease, ie, recurrent acute calcium pyrophosphate (CPP) crystal arthritis, chronic CPP crystal inflammatory arthritis, and crowned dens syndrome (CDS).

Methods: Data from an international cohort (assembled from 25 sites in 7 countries for the development and validation of the 2023 CPPD classification criteria from the American College of Rheumatology/EULAR) that met the criteria were included. Three cross-sectional studies were conducted to determine the phenotypic characteristics of recurrent acute CPP crystal arthritis, chronic CPP crystal inflammatory arthritis, and CDS. Multivariable logistic regression analysis was used to calculate adjusted odds ratio (aOR) and 95% confidence interval (CI) to examine the association between potential risk factors and the inflammatory phenotype.

Results: Among the 618 people included (56% female; mean age [standard deviation] 74.0 [11.9] years), 602 (97.4%) had experienced acute CPP crystal arthritis, 332 (53.7%) had recurrent acute arthritis, 158 (25.6%) had persistent inflammatory arthritis, and 45 (7.3%) had had CDS. Recurrent acute CPP crystal arthritis associated with longer disease duration (aOR 2.88 [95% CI 2.00-4.14]). Chronic CPP crystal inflammatory arthritis was associated with acute wrist arthritis (aOR 2.92 [95% CI 1.81-4.73]), metacarpophalangeal joint osteoarthritis (aOR 1.87 [95% CI 1.17-2.97]), and scapho-trapezo-trapezoid (STT) joint osteoarthritis (aOR 1.83 [95% CI 1.15-2.91]), and it was negatively associated with either metabolic or familial risk for CPPD (aOR 0.60 [95% CI 0.37-0.96]). CDS was associated with male sex (aOR 2.35 [95% CI 1.21-4.59]), STT joint osteoarthritis (aOR 2.71 [95% CI 1.22-6.05]), and more joints affected with chondrocalcinosis (aOR 1.46 [95% CI 1.15-1.85]).

Conclusion: CPPD disease encompasses acute and chronic inflammatory phenotypes, each with specific clinical and imaging features that need to be considered in the diagnostic workup.

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.