精细化工和制药生产的再定位

IF 3.1 3区化学 Q2 CHEMISTRY, APPLIED

Organic Process Research & Development Pub Date : 2024-07-30 DOI:10.1021/acs.oprd.4c00219

Rosaria Ciriminna, Cristina Della Pina, Rafael Luque, Mario Pagliaro

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引用次数: 0

摘要

许多不生产极其重要的原料药的国家长期缺乏原料药，因此急需调整上述精细化工产品的生产。而全球供应链的频繁中断（先是 COVID-19 危机，后是当前的红海危机）使情况更加恶化。在本研究中，我们首先概述了原料药生产向欧洲转移的选定案例中出现的主要经济和政策问题。随后，我们将分析范围扩大到中国和印度的部分案例，调查精细化学品生产中对连续生产的产业吸收情况。在对具体情况进行具体分析后，本研究得出了三项主要结论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Reshoring Fine Chemical and Pharmaceutical Productions

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Reshoring Fine Chemical and Pharmaceutical Productions

Prolonged shortage of active pharmaceutical ingredients (APIs) in many countries that do not produce critically important APIs requires urgent reshoring of the said fine chemical productions. The situation is even worsened by frequent disruption of the global supply chains, first during the COVID-19 crisis and subsequently with the ongoing Red Sea crisis. In this study, we first outline the main economic and policy aspects emerging from selected cases of reshoring of API production to Europe. Hence, broadening the analysis to include selected cases in China and India, we investigate the industrial uptake of continuous manufacturing in fine chemicals production. Following said concrete analysis of the concrete situation, the study concludes with three main findings.

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.