FeCl3/K2S2O8/Et3SiH体系介导的β-酮砜与DMF的α-甲基化反应

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2024-07-30 DOI:10.1002/adsc.202400476

Meng-Yang Chang, Chi-Ru Yang

引用次数: 0

摘要

开发了 FeCl3/K2S2O8/Et3SiH 系统介导的 N,N-二甲基甲酰胺（DMF）α-甲基化 β-酮砜。在整个过程中，DMF 在回流条件下通过单碳碳（C-C）键的形成，在生成 α-甲基 β-酮砜的过程中扮演了一个甲基的角色。在此提出了一种合理的反应机制。

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FeCl3/K2S2O8/Et3SiH System-Mediated α-Methylation of β-Ketosulfones with DMF

FeCl3/K2S2O8/Et3SiH system-mediated α-methylation of β-ketosulfones with N,N-dimethylformamide (DMF) was developed. In the overall process, DMF takes up the role of one methyl group in the generation of α-methyl β-ketosulfones via single carbon-carbon (C-C) bond formation under the reflux condition. Herein, a plausible reaction mechanism is proposed.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.