多巴胺在葡萄糖和脂质代谢调节中的作用:综述。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Obesity Pub Date : 2024-07-30 DOI:10.1002/oby.24068
Zhehong Li, Lifei Zheng, Jing Wang, Liang Wang, Yao Qi, Buhe Amin, Jinxia Zhu, Nengwei Zhang
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引用次数: 0

摘要

目的:由于全球肥胖症的流行,了解葡萄糖和脂质代谢的调节机制变得越来越重要。多巴胺能系统,包括多巴胺、多巴胺受体、多巴胺转运体和其他成分,参与了许多生理和病理过程。然而,人们对多巴胺能系统在葡萄糖和脂质代谢中的作用机制却知之甚少。在这篇综述中,我们研究了多巴胺能系统在葡萄糖和脂质代谢中的作用:多巴胺能系统通过多种机制调节葡萄糖和脂质代谢。它在中枢水平调节各种活动,包括食欲控制和决策,有助于调节体重和能量代谢。在垂体中,多巴胺可抑制催乳素分泌,并通过多巴胺受体 2 促进胰岛素分泌。此外,多巴胺还能通过调节胰岛素和胰高血糖素的分泌、葡萄糖的摄取和利用以及脂肪酸的代谢,影响胰腺β细胞、胰高血糖素样肽-1、脂肪细胞、肝细胞和肌肉等外周系统的各种生理成分:结论:多巴胺在调节葡萄糖和脂质代谢中的作用对疾病的生理和发病机制具有重要意义。多巴胺的潜在治疗价值在于其对代谢紊乱的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dopamine in the regulation of glucose and lipid metabolism: a narrative review

Objective

Owing to the global obesity epidemic, understanding the regulatory mechanisms of glucose and lipid metabolism has become increasingly important. The dopaminergic system, including dopamine, dopamine receptors, dopamine transporters, and other components, is involved in numerous physiological and pathological processes. However, the mechanism of action of the dopaminergic system in glucose and lipid metabolism is poorly understood. In this review, we examine the role of the dopaminergic system in glucose and lipid metabolism.

Results

The dopaminergic system regulates glucose and lipid metabolism through several mechanisms. It regulates various activities at the central level, including appetite control and decision-making, which contribute to regulating body weight and energy metabolism. In the pituitary gland, dopamine inhibits prolactin production and promotes insulin secretion through dopamine receptor 2. Furthermore, it can influence various physiological components in the peripheral system, such as pancreatic β cells, glucagon-like peptide-1, adipocytes, hepatocytes, and muscle, by regulating insulin and glucagon secretion, glucose uptake and use, and fatty acid metabolism.

Conclusions

The role of dopamine in regulating glucose and lipid metabolism has significant implications for the physiology and pathogenesis of disease. The potential therapeutic value of dopamine lies in its effects on metabolic disorders.

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来源期刊
Obesity
Obesity 医学-内分泌学与代谢
CiteScore
11.70
自引率
1.40%
发文量
261
审稿时长
2-4 weeks
期刊介绍: Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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