内在能力及其生物学基础：范围审查。

IF 3.3 Q2 GERIATRICS & GERONTOLOGY

Journal of Frailty & Aging Pub Date : 2024-01-01 DOI:10.14283/jfa.2024.30

M B Beyene, R Visvanathan, A T Amare

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引用次数: 0

摘要

背景：2015 年，世界卫生组织（WHO）提出了内在能力（IC）的概念，以功能能力为基础定义健康老龄化。在这篇范围综述中，我们总结了有关 IC 指数评分的开发和验证、IC 与健康相关因素的关联及其生物学基础的现有证据。综述的重点是确定当前的研究空白、利用生物库数据集的拟议策略，以及研究 IC 的遗传机制和基因与环境相互作用的机会：使用与 IC 相关的关键词在 PubMed、CINAHL、Web of Science、Scopus、AgeLine 和 PsycINFO 等六个数据库中进行文献检索：本综述共收录了 84 篇文章，其中大多数文章（38 篇）采用了五领域方法，利用相关的五因素或双因素结构来操作 IC。内在能力一直与社会人口学和健康相关结果有显著关联，包括年龄、性别、财富指数、营养、运动、吸烟、饮酒、ADL、IADL、虚弱、多病症和死亡率。虽然对综合 IC 的生物学基础的研究有限，只有一项研究发现与载脂蛋白 E 基因变异有显著关联，但对特定 IC 领域（运动、活力、认知、心理和感官）的研究表明，IC 的遗传率为 20-85%，并且已经发现了与这些子领域相关的几个基因变异。然而，关于遗传和环境因素如何影响 IC 的证据仍然缺乏，迄今为止还没有任何研究：我们的综述发现，在使用标准化的 IC 测量工具和指标方面存在不一致性，但 IC 指数显示出良好的构建和预测有效性。目前仍缺乏对遗传因素和基因与环境之间相互作用的研究，这就需要在未来利用大型生物库数据集的资源。

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Intrinsic Capacity and Its Biological Basis: A Scoping Review.

Background: In 2015, the World Health Organization (WHO) introduced the concept of intrinsic capacity (IC) to define healthy aging based on functional capacity. In this scoping review, we summarized available evidence on the development and validation of IC index scores, the association of IC with health-related factors, and its biological basis. The review specifically focused on identifying current research gaps, proposed strategies to leverage biobank datasets, and opportunities to study the genetic mechanisms and gene-environment interactions underlying IC.

Methods: The literature search was conducted across six databases, including PubMed, CINAHL, Web of Science, Scopus, AgeLine, and PsycINFO, using keywords related to IC.

Results: This review included 84 articles, and most of them (n=38) adopted the 5-domains approach to operationalize IC, utilizing correlated five factors or bifactor structures. Intrinsic capacity has consistently shown significant associations with socio-demographic and health-related outcomes, including age, sex, wealth index, nutrition, exercise, smoking, alcohol use, ADL, IADL, frailty, multimorbidity, and mortality. While studies on the biological basis of the composite IC are limited, with only one study finding a significant association with the ApoE gene variants, studies on specific IC domains - locomotor, vitality, cognitive, psychological, and sensory suggest a heritability of 20-85% of IC and several genetic variants associated with these subdomains have been identified. However, evidence on how genetic and environmental factors influence IC is still lacking, with no available study to date.

Conclusion: Our review found that there was inconsistency in the use of standardized IC measurement tools and indicators, but the IC indices had shown good construct and predictive validity. Research into the genetic and gene-to-environment interactions underlying IC is still lacking, which calls for the use of resources from large biobank datasets in the future.

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来源期刊

Journal of Frailty & Aging GERIATRICS & GERONTOLOGY-

CiteScore

5.90

自引率

7.70%

发文量

期刊介绍： The Journal of Frailty & Aging is a peer-reviewed international journal aimed at presenting articles that are related to research in the area of aging and age-related (sub)clinical conditions. In particular, the journal publishes high-quality papers describing and discussing social, biological, and clinical features underlying the onset and development of frailty in older persons. The Journal of Frailty & Aging is composed by five different sections: - Biology of frailty and aging In this section, the journal presents reports from preclinical studies and experiences focused at identifying, describing, and understanding the subclinical pathophysiological mechanisms at the basis of frailty and aging. - Physical frailty and age-related body composition modifications Studies exploring the physical and functional components of frailty are contained in this section. Moreover, since body composition plays a major role in determining physical frailty and, at the same time, represents the most evident feature of the aging process, special attention is given to studies focused on sarcopenia and obesity at older age. - Neurosciences of frailty and aging The section presents results from studies exploring the cognitive and neurological aspects of frailty and age-related conditions. In particular, papers on neurodegenerative conditions of advanced age are welcomed. - Frailty and aging in clinical practice and public health This journal’s section is devoted at presenting studies on clinical issues of frailty and age-related conditions. This multidisciplinary section particularly welcomes reports from clinicians coming from different backgrounds and specialties dealing with the heterogeneous clinical manifestations of advanced age. Moreover, this part of the journal also contains reports on frailty- and age-related social and public health issues. - Clinical trials and therapeutics This final section contains all the manuscripts presenting data on (pharmacological and non-pharmacological) interventions aimed at preventing, delaying, or treating frailty and age-related conditions.The Journal of Frailty & Aging is a quarterly publication of original papers, review articles, case reports, controversies, letters to the Editor, and book reviews. Manuscripts will be evaluated by the editorial staff and, if suitable, by expert reviewers assigned by the editors. The journal particularly welcomes papers by researchers from different backgrounds and specialities who may want to share their views and experiences on the common themes of frailty and aging.The abstracting and indexing of the Journal of Frailty & Aging is covered by MEDLINE (approval by the National Library of Medicine in February 2016).