从老年人的角度看干预措施对 "肌肉疏松症 "的影响:系统性文献综述。

IF 3.3 Q2 GERIATRICS & GERONTOLOGY
G L Doza, S van Heden, F Oliveira Felix, V Singh, C Beaudart
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引用次数: 0

摘要

目前针对肌肉疏松症的干预措施多种多样,融合了营养、运动和药物策略。虽然肌肉质量、肌肉力量或功能表现通常作为主要终点,但监管机构最近强调将患者报告结果测量指标(PROMs)作为干预研究的主要或次要结果。这种转变承认了 PROMs 和 "患者体验报告"(Patient-Reported Experience Measures,PREMs)在评估干预效果方面的重要性,并与以患者为中心的医疗保健模式相一致。本系统性综述的目的是:1)识别所有以 PROMs/PREMs 作为主要或次要结果的肌肉疏松症设计干预研究;2)识别这些研究中使用的不同 PROMs/PREMs ;3)总结肌肉疏松症设计干预对肌肉疏松参与者的 PROMs/PREMs 的影响。为此,我们于 2023 年 9 月对数据库(Medline、EMBASE、Review- Cochrane Central of Register of Controlled Trials 和 PsychINFO (Via Ovid))进行了系统性检索。综述遵循了系统综述和元分析首选报告项目(PRISMA)声明,综述方案在开放科学框架(https://osf.io/zxgwm/)上进行了注册。该系统性综述确定了 17 项研究性临床试验,它们都是由肌肉疏松症设计的、报告 PROMs 的干预性研究。PROMs 涵盖了生活质量、抑郁症状、孤独感/社会隔离、白天嗜睡、失眠影响以及睡眠质量/干扰等各个方面的评估。报告中只有一个专门针对肌肉疏松症的 PROM,即 SarQoL。由肌肉疏松症设计的干预措施对 PROMs 的影响显示出相当大的异质性,这突出表明有必要通过开发核心结果集(COS)来实现肌肉疏松症研究的标准化。肌肉疏松症研究中的核心结果集将确保研究结果的一致性和可比性,最终提高干预措施的可靠性和有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Interventions on Sarcopenia from the Perspective of Older Persons: A Systematic Literature Review.

Current interventions targeting sarcopenia are diverse, incorporating a blend of nutritional, exercise, and pharmacological strategies. Although muscle mass, muscle strength, or functional performance typically serve as the primary endpoints, regulatory agencies have recently emphasized integrating Patient-Reported Outcome Measures (PROMs) as primary or secondary outcomes in interventional studies. This shift acknowledges the importance of PROMs and Patient-Reported Experience Measures (PREMs) in assessing intervention effectiveness and aligns with patient-centered healthcare models. The aims of this systematic review are 1) to identify all sarcopenia-designed interventional studies that used PROMs/PREMs as the primary or secondary outcome, 2) to identify the different PROMs/PREMs used within those studies, and 3) to summarize the effects of sarcopenia-designed interventions on PROMs/PREMs of sarcopenic participants. For that, a systematic search of databases (Medline, EMBASE, Review- Cochrane Central of Register of Controlled Trials, and PsychINFO (Via Ovid)) was conducted in September 2023. The review followed the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) statement, and the protocol was registered on Open Science Framework (https://osf.io/zxgwm/). The systematic review identified 17 RCTs as sarcopenia-designed interventional studies reporting PROMs. PROMs covered the assessment of various aspects, including quality of life, depressive symptoms, loneliness/social isolation, daytime sleepiness, insomnia impact, and sleep quality/disturbance. Only one sarcopenia-specific PROM, namely the SarQoL, was reported. The effect of sarcopenia-designed interventions on PROMs showed considerable heterogeneity, underscoring the need for standardization in sarcopenia research by developing a Core Outcome Set (COS). COS in sarcopenia studies would ensure consistent and comparable findings, ultimately enhancing the reliability and effectiveness of interventions.

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来源期刊
Journal of Frailty & Aging
Journal of Frailty & Aging GERIATRICS & GERONTOLOGY-
CiteScore
5.90
自引率
7.70%
发文量
54
期刊介绍: The Journal of Frailty & Aging is a peer-reviewed international journal aimed at presenting articles that are related to research in the area of aging and age-related (sub)clinical conditions. In particular, the journal publishes high-quality papers describing and discussing social, biological, and clinical features underlying the onset and development of frailty in older persons.          The Journal of Frailty & Aging is composed by five different sections: - Biology of frailty and aging In this section, the journal presents reports from preclinical studies and experiences focused at identifying, describing, and understanding the subclinical pathophysiological mechanisms at the basis of frailty and aging. - Physical frailty and age-related body composition modifications Studies exploring the physical and functional components of frailty are contained in this section. Moreover, since body composition plays a major role in determining physical frailty and, at the same time, represents the most evident feature of the aging process, special attention is given to studies focused on sarcopenia and obesity at older age. - Neurosciences of frailty and aging The section presents results from studies exploring the cognitive and neurological aspects of frailty and age-related conditions. In particular, papers on neurodegenerative conditions of advanced age are welcomed. - Frailty and aging in clinical practice and public health This journal’s section is devoted at presenting studies on clinical issues of frailty and age-related conditions. This multidisciplinary section particularly welcomes reports from clinicians coming from different backgrounds and specialties dealing with the heterogeneous clinical manifestations of advanced age. Moreover, this part of the journal also contains reports on frailty- and age-related social and public health issues. - Clinical trials and therapeutics This final section contains all the manuscripts presenting data on (pharmacological and non-pharmacological) interventions aimed at preventing, delaying, or treating frailty and age-related conditions.The Journal of Frailty & Aging is a quarterly publication of original papers, review articles, case reports, controversies, letters to the Editor, and book reviews. Manuscripts will be evaluated by the editorial staff and, if suitable, by expert reviewers assigned by the editors. The journal particularly welcomes papers by researchers from different backgrounds and specialities who may want to share their views and experiences on the common themes of frailty and aging.The abstracting and indexing of the Journal of Frailty & Aging is covered by MEDLINE (approval by the National Library of Medicine in February 2016).
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