中性粒细胞、嗜酸性粒细胞和巨噬细胞释放的细胞外捕获物在哮喘中的作用。

IF 5.8 2区医学 Q1 Medicine

Respiratory Research Pub Date : 2024-07-30 DOI:10.1186/s12931-024-02923-x

Wei Gu, Chunli Huang, Gongqi Chen, Weiqiang Kong, Lu Zhao, Huiru Jie, Guohua Zhen

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引用次数: 0

摘要

细胞外捕获物（ETs）是先天性免疫防御的一种特殊形式，白细胞释放由染色质和活性蛋白组成的 ETs 来消灭病原微生物。除了 ETs 的抗感染作用外，研究人员还发现它们参与了炎症性疾病、肿瘤、自身免疫性疾病和过敏性疾病的发病机制。哮喘是一种涉及多种免疫细胞的慢性气道炎症性疾病。哮喘患者体内 ETs 水平的升高表明，ETs 在哮喘的发病机制中扮演着重要角色。在此，我们将综述有关哮喘中嗜中性粒细胞、嗜酸性粒细胞和巨噬细胞释放的 ETs 的形成机制、作用和治疗策略的研究工作。

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The role of extracellular traps released by neutrophils, eosinophils, and macrophages in asthma.

Extracellular traps (ETs) are a specialized form of innate immune defense in which leukocytes release ETs composed of chromatin and active proteins to eliminate pathogenic microorganisms. In addition to the anti-infection effect of ETs, researchers have also discovered their involvement in the pathogenesis of inflammatory disease, tumors, autoimmune disease, and allergic disease. Asthma is a chronic airway inflammatory disease involving multiple immune cells. The increased level of ETs in asthma patients suggests that ETs play an important role in the pathogenesis of asthma. Here we review the research work on the formation mechanism, roles, and therapeutic strategies of ETs released by neutrophils, eosinophils, and macrophages in asthma.

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来源期刊

Respiratory Research RESPIRATORY SYSTEM-

CiteScore

9.70

自引率

1.70%

发文量

314

审稿时长

4-8 weeks

期刊介绍： Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases. As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion. Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.