Serdar Aykut, Suleyman Cansun Demir, Ismaıl Cuneyt Evruke, Mete Sucu, Fatma Islek Uzay, Mesut Avan, Ozge Keles Bayer, Emre Yalcin
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引用次数: 0
摘要
胎儿和新生儿溶血病（HDFN）是指红细胞表面抗原的抗体从胎盘转移到胎儿体内，导致胎儿发生贫血、高胆红素血症，最后导致胎儿水肿。最常见的原因是 D-HDFN。凯尔血型系统中的 K（KEL1）是所有血型抗原中仅次于 D 的最强免疫原。0.1-0.3% 的孕妇会出现 K-HDFN。在抗体介导的严重胎儿贫血病例中，K-HDFN 占 10%。我们介绍了一个成功处理 Kell 同种免疫的案例，该孕妇曾因 K-HDFN 导致 3 次妊娠流产和胎儿水肿，在最后一次妊娠的产后阶段被证实患有 K-HDFN。
Approach to Pregnancy Affected by Kell Alloimmunization.
Hemolytic disease of the fetus and newborn (HDFN) is the development of anemia, hyperbilirubinemia, and finally hydrops fetalis in the fetus when antibodies to antigens on the surface of erythrocytes are transferred from the placenta to the fetus. The most common cause is D-HDFN. K (KEL1) from the Kell blood group system is the most potent immunogenic antigen after D among all blood group antigens. K-HDFN occurs in 0.1-0.3% of pregnant women. It accounts for 10% of cases of antibody-mediated severe fetal anemia. We present a successful management of Kell alloimmunization in a pregnant woman who had 3 times pregnancy loss with hydrops fetalis due to K-HDFN and who was proven to have K-HDFN in the postnatal period in her last pregnancy.
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