评估严重急性呼吸系统综合征冠状病毒 2 感染对血液学参数的影响。

IF 1.9 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Badi A Alotaibi, Jehad A Aldali, Hamzah J Aldali, Ali Alaseem, Abdulaziz M Almuqrin, Abdulrahman Alshalani, Hamood AlSudais, Nasser A Alshehri, Nasser B Alamar, Mogtba A Alhejji
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引用次数: 0

摘要

研究背景本研究是一项回顾性研究,旨在评估沙特一家著名的三级中心2019年冠状病毒病(COVID-19)成人患者全血细胞计数和凝血参数的变化,以预测疾病的严重程度和死亡率:研究对象包括74 800名成年患者,根据COVID-19检测结果和患者性别分为四组:女性COVID-19阴性组35 985人,男性COVID-19阴性组23 278人,女性COVID-19阳性组8846人,男性COVID-19阳性组6691人:结果:COVID-19 患者的白细胞计数减少,红细胞计数增加。此外,与 COVID-19 阴性受试者相比,COVID-19 阳性受试者的部分凝血活酶时间更长,D-二聚体水平更低:根据研究结果,与 COVID-19 相关的血细胞计数和凝血能力的改变可能是导致死亡的风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessing the impact of severe acute respiratory syndrome coronavirus 2 infection on hematological parameters.

Background: The current study is a retrospective study designed to evaluate changes in complete blood count and coagulation parameters in adult coronavirus disease 2019 (COVID-19) patients at a prominent Saudi tertiary center to predict disease severity and mortality.

Methods: The cohort consisted of 74 800 adult patients divided into four groups based on a COVID-19 test and the patient's sex: 35 985 in the female negative COVID-19 group, 23 278 in the male negative COVID-19 group, 8846 in the female positive COVID-19 group and 6691 in the male positive COVID-19 group.

Results: Patients with COVID-19 demonstrated decreased white blood cell counts and increased red blood cell counts. Also, COVID-19-positive participants exhibited more prolonged partial thromboplastin time and lower D-dimer levels than those of COVID-19-negative subjects (p<0.05). The study also revealed gender-dependent impacts on platelet counts, implying a possible relationship with the greater infection mortality rate in men than in women (p<0.001). In addition, the study found a link between changes in coagulation test results and death in COVID-19 patients (p<0.001). The evidence regarding the effects of COVID-19 on blood cell counts and coagulation, on the other hand, is conflicting, most likely due to variances in study populations and the timing of testing postinfection.

Conclusions: According to the findings, COVID-19-related alterations in blood cell count and clotting ability may be risk factors for death.

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来源期刊
Transactions of The Royal Society of Tropical Medicine and Hygiene
Transactions of The Royal Society of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生
CiteScore
4.00
自引率
9.10%
发文量
115
审稿时长
4-8 weeks
期刊介绍: Transactions of the Royal Society of Tropical Medicine and Hygiene publishes authoritative and impactful original, peer-reviewed articles and reviews on all aspects of tropical medicine.
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