通过对双胞胎新生儿进行全外显子组测序，深入了解严重新生儿 COVID-19。

IF 2.9 4区医学 Q3 IMMUNOLOGY

Pediatric Infectious Disease Journal Pub Date : 2024-07-31 DOI:10.1097/INF.0000000000004501

Jennie Godwin, John Daniel, Susana Chavez-Bueno, Venkatesh Sampath

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引用次数: 0

摘要

新生儿 COVID-19 感染的严重程度不一，其遗传基础尚未得到研究。我们通过对一名患重症 COVID-19 肺炎和多系统炎症综合征的婴儿以及同样对重症急性呼吸道综合征-冠状病毒-2 呈阳性但只有中度呼吸道症状的双胞胎兄弟进行全外显子测序，发现了涉及抗病毒免疫反应的共有和独特遗传变异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Insight Into Severe Neonatal COVID-19 Gained Through Whole Exome Sequencing of Twin Neonates.

The genetic basis of neonatal COVID-19 infection, which exhibits a range of severity, has not been investigated. We identified both shared and unique genetic variants involved in antiviral immune responses through whole exome sequencing of an infant who developed severe COVID-19 pneumonia and multisystem inflammatory syndrome and the twin brother also positive for severe acute respiratory syndrome-coronavirus-2, but with only moderate respiratory symptoms.

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来源期刊

Pediatric Infectious Disease Journal 医学-传染病学

CiteScore

6.30

自引率

2.80%

发文量

566

审稿时长

2-4 weeks

期刊介绍： The Pediatric Infectious Disease Journal® (PIDJ) is a complete, up-to-the-minute resource on infectious diseases in children. Through a mix of original studies, informative review articles, and unique case reports, PIDJ delivers the latest insights on combating disease in children — from state-of-the-art diagnostic techniques to the most effective drug therapies and other treatment protocols. It is a resource that can improve patient care and stimulate your personal research.