将对称二甲基精氨酸作为条纹鼬(Mephitis mephitis)肾功能血清学标记的研究。

IF 1.5 3区 农林科学 Q2 VETERINARY SCIENCES
Eun Jung, Soong-Hee Youn, Ki-Yong Shin, Hyeon-Joo Shin, Joon-Young Yang, Yeseul Yang, Jae-Ha Jung, Yongbaek Kim
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引用次数: 0

摘要

重要性:肾脏疾病是包括动物园动物在内的兽医物种的常见病;然而,对条纹臭鼬(Mephitis mephitis)肾脏疾病的调查却很少。该物种肾脏疾病的诊断工具也仍然有限:本研究旨在评估对称二甲基精氨酸作为韩国圈养条纹臭鼬肾脏疾病生物标志物的实用性:这项回顾性研究分析了 2017 年至 2021 年期间在 Everland 动物园饲养的 11 只条纹鼬。在健康检查期间采集了血液样本。通过血液分析和超声波诊断评估肾功能,并对死亡动物进行尸体解剖。从 11 只臭鼬身上采集的 27 份血浆样本中测量了对称二甲基精氨酸水平:结果:在研究期间,有 7 只臭鼬被诊断出患有肾病。对 27 份血液样本的分析表明,SDMA 水平随血尿素氮和血肌酐浓度的增加而增加。在 7 只患有肾病的臭鼬中,有 3 只在血尿素氮和血肌酐超过参考上限之前,对称二甲基精氨酸的含量就已超过 14 µg/dL:据我们所知,这是首次对韩国圈养条纹短尾鼬的对称二甲基精氨酸进行研究。我们的研究结果表明,对称二甲基精氨酸可作为条纹短尾鼬肾功能障碍的早期和一致的生物标志物。要验证血液中对称二甲基精氨酸浓度的临床实用性,还需要对条纹短尾鼬进行更大临床样本量的进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigation of symmetric dimethylarginine as a serologic marker for kidney function in striped skunks (Mephitis mephitis).

Importance: Kidney disease is prevalent among veterinary species, including zoo animals; however, investigations into this condition in striped skunks (Mephitis mephitis) are scarce. Diagnostic tools for kidney diseases in this species also remain limited.

Objective: This study aimed to assess the utility of symmetric dimethylarginine as a biomarker for kidney disease in captive striped skunks in Korea.

Methods: This retrospective study analysed 11 striped skunks housed at the Everland Zoo between 2017 and 2021. Blood samples were collected during health checks. Kidney function was assessed through blood analysis and diagnostic ultrasound, with necropsies conducted on deceased animals. Symmetric dimethylarginine levels were measured in 27 plasma samples collected from 11 skunks.

Results: Over the study period, seven skunks were diagnosed with kidney disease. Analysis of 27 blood samples revealed a concurrent increase in SDMA levels with concentrations of blood urea nitrogen and blood creatinine. In 3 of the 7 skunks with kidney disease, symmetric dimethylarginine exceeded 14 µg/dL prior to the elevation of blood urea nitrogen and blood creatinine above the upper reference limit.

Conclusions and relevance: To our knowledge, this is the first study investigating symmetric dimethylarginine in captive striped skunks in Korea. Our findings suggest that symmetric dimethylarginine may serve as an early and consistent biomarker for renal dysfunction in striped skunks. Further studies with larger clinical sample size from striped skunks are needed to validate the clinical utility of blood symmetric dimethylarginine concentration.

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来源期刊
Journal of Veterinary Science
Journal of Veterinary Science 农林科学-兽医学
CiteScore
3.10
自引率
5.60%
发文量
86
审稿时长
1.3 months
期刊介绍: The Journal of Veterinary Science (J Vet Sci) is devoted to the advancement and dissemination of scientific knowledge concerning veterinary sciences and related academic disciplines. It is an international journal indexed in the Thomson Scientific Web of Science, SCI-EXPANDED, Sci Search, BIOSIS Previews, Biological Abstracts, Focus on: Veterinary Science & Medicine, Zoological Record, PubMed /MEDLINE, Index Medicus, Pubmed Central, CAB Abstracts / Index Veterinarius, EBSCO, AGRIS and AGRICOLA. This journal published in English by the Korean Society of Veterinary Science (KSVS) being distributed worldwide.
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