强化血压控制与标准血压控制对透析或肾移植发生率的遗产效应。

IF 10.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Nicholas M Pajewski, Srinivasan Beddhu, Adam P Bress, Tara I Chang, Glenn M Chertow, Alfred K Cheung, William C Cushman, Barry I Freedman, Tom Greene, Karen C Johnson, Byron C Jaeger, Manjula Kurella Tamura, Cora E Lewis, Mahboob Rahman, David M Reboussin, Michael V Rocco, Jeff D Williamson, Paul K Whelton, Jackson T Wright, Paul E Drawz, Joachim H Ix
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引用次数: 0

摘要

背景:收缩压干预试验(SPRINT)显示,强化降低收缩压(BP)会增加慢性肾病和急性肾损伤的发病风险。强化治疗是否会改变肾衰竭的风险尚不清楚。本研究的目的是估算强化降压与标准降压对肾衰竭长期发病率的遗留影响:方法:对一项随机、开放标签临床试验进行二次分析,并进行观察性随访。2010 年至 2013 年间,美国和波多黎各的 102 个诊所招募了 50 岁及以上的高血压和心血管风险较高的患者,其中不包括糖尿病、中风病史、蛋白尿大于 1 克/天或多囊肾患者。参与者被随机设定收缩压目标:根据对 9361 名随机参与者中 9279 人(99.1%)的分析,中位随访 8.6 年(四分位数间距为 8.0 至 9.1 年)期间发生了 101 例肾衰竭,其中大多数发生在 74 名(73.3%)eGFRConclusions.患者身上:总体而言,eGFR
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Legacy Effect of Intensive versus Standard BP Control on the Incidence of Needing Dialysis or Kidney Transplantation.
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来源期刊
Journal of The American Society of Nephrology
Journal of The American Society of Nephrology 医学-泌尿学与肾脏学
CiteScore
22.40
自引率
2.90%
发文量
492
审稿时长
3-8 weeks
期刊介绍: The Journal of the American Society of Nephrology (JASN) stands as the preeminent kidney journal globally, offering an exceptional synthesis of cutting-edge basic research, clinical epidemiology, meta-analysis, and relevant editorial content. Representing a comprehensive resource, JASN encompasses clinical research, editorials distilling key findings, perspectives, and timely reviews. Editorials are skillfully crafted to elucidate the essential insights of the parent article, while JASN actively encourages the submission of Letters to the Editor discussing recently published articles. The reviews featured in JASN are consistently erudite and comprehensive, providing thorough coverage of respective fields. Since its inception in July 1990, JASN has been a monthly publication. JASN publishes original research reports and editorial content across a spectrum of basic and clinical science relevant to the broad discipline of nephrology. Topics covered include renal cell biology, developmental biology of the kidney, genetics of kidney disease, cell and transport physiology, hemodynamics and vascular regulation, mechanisms of blood pressure regulation, renal immunology, kidney pathology, pathophysiology of kidney diseases, nephrolithiasis, clinical nephrology (including dialysis and transplantation), and hypertension. Furthermore, articles addressing healthcare policy and care delivery issues relevant to nephrology are warmly welcomed.
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