甘草提取物与低热量饮食相结合对多囊卵巢综合征（PCOS）超重/肥胖妇女的肥胖指数、血糖指数和血脂概况的影响：随机、双盲、安慰剂对照试验。

IF 3.8 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research Pub Date : 2024-07-30 DOI:10.1186/s13048-024-01446-9

Hadis Hooshmandi, Akram Ghadiri-Anari, Ali Mohammad Ranjbar, Hossein Fallahzadeh, Mahdieh Hosseinzadeh, Azadeh Nadjarzadeh

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引用次数: 0

摘要

背景：多囊卵巢综合征（PCOS多囊卵巢综合征（PCOS）是最常见的卵巢功能障碍。最近的研究表明，甘草对新陈代谢的影响并不一致。因此，我们研究了甘草对多囊卵巢综合征女性肥胖指数、血糖指数和血脂状况的影响：这项随机、双盲、安慰剂对照试验是针对 66 名患有多囊卵巢综合征的超重/肥胖女性进行的。参与者被随机分配接受每天 1.5 克甘草提取物加低热量饮食（33 人）或安慰剂加低热量饮食（33 人），为期 8 周。采用标准方案对参与者的人体测量指数和身体成分进行评估。使用酶试剂盒测量空腹血糖（FBS）、胰岛素水平、低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）。使用有效公式计算胰岛素抵抗的稳态模型评估（HOMA-IR）和β细胞功能的 HOMA（HOMA-B）：组间比较显示，研究结束时，各组在肥胖指数（体重、体重指数和体脂）、血脂概况（TG、TC、LDL-C 和 HDL-C）、FBS 和胰岛素水平、HOMA-IR 和 HOMA-B 等方面均存在显著差异（P 结论：研究结果表明，食用甘草能降低肥胖指数和血脂概况（TG、TC、LDL-C 和 HDL-C）：研究结果表明，与安慰剂相比，服用甘草可改善肥胖指数、糖稳态和血脂状况。由于该研究可能存在局限性，因此需要进一步的研究来证实这些发现。

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Effects of licorice extract in combination with a low-calorie diet on obesity indices, glycemic indices, and lipid profiles in overweight/obese women with polycystic ovary syndrome (PCOS): a randomized, double-blind, placebo-controlled trial.

Background: Polycystic ovary syndrome (PCOS) is the most common ovarian dysfunction. Recent studies showed the effectiveness of licorice on metabolic profiles with inconsistent findings. So, we investigated the effect of licorice on obesity indices, glycemic indices, and lipid profiles in women with PCOS.

Methods: This randomized, double-blind, placebo-controlled trial was performed on 66 overweight/obese women with PCOS. The participants were randomly assigned to receive either 1.5 gr/day licorice extract plus a low-calorie diet (n = 33) or placebo plus a low-calorie diet (n = 33) for 8 weeks. Participants' anthropometric indices and body composition were assessed using standard protocols. Fasting blood sugar (FBS), insulin levels, low-density lipoprotein-cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG), and high-density lipoprotein-cholesterol (HDL-C) were measured using enzymatic kits. The homeostasis model assessment-insulin resistance (HOMA-IR) and HOMA of β-cell function (HOMA-B) were calculated using valid formulas.

Results: Between-group comparisons demonstrated significant differences between the groups in terms of obesity indices (body weight, BMI, and body fat), lipid profiles (TG, TC, LDL-C, and HDL-C), FBS and insulin levels, HOMA-IR, and HOMA-B at the end of the study (P < 0.05). Supplementation with licorice plus a low-calorie diet was also more effective in improving all parameters than a low-calorie diet alone after adjusting for confounders (baseline values, age, weight changes, and physical activity changes) (P < 0.05).

Conclusion: The findings showed that licorice consumption leads to improvements in obesity indices, glucose homeostasis, and lipid profiles compared to placebo. Due to possible limitations of the study, further research is needed to confirm these findings.

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来源期刊

Journal of Ovarian Research REPRODUCTIVE BIOLOGY-

CiteScore

6.20

自引率

2.50%

发文量

125

审稿时长

>12 weeks

期刊介绍： Journal of Ovarian Research is an open access, peer reviewed, online journal that aims to provide a forum for high-quality basic and clinical research on ovarian function, abnormalities, and cancer. The journal focuses on research that provides new insights into ovarian functions as well as prevention and treatment of diseases afflicting the organ. Topical areas include, but are not restricted to: Ovary development, hormone secretion and regulation Follicle growth and ovulation Infertility and Polycystic ovarian syndrome Regulation of pituitary and other biological functions by ovarian hormones Ovarian cancer, its prevention, diagnosis and treatment Drug development and screening Role of stem cells in ovary development and function.