Evaluation of the Variability of AIZE Rapid Tests on the "imo" Perimeter In Stable Glaucoma Patients.

Prcis: Analysis of AIZE Rapid test variability in stable glaucoma patients showed that the 95% prediction interval of the MD value, potentially an index for judging progression, was ±1.63 to ±1.78 dB in early-to-moderate-stage patients.

Purpose: To explore the 95% prediction interval of the mean deviation (MD) value using the AIZE Rapid test strategy for glaucoma observation.

Method: This study included seventy-two patients with stable or suspected glaucoma who underwent the imo AIZE Rapid test three times or more within two years. Both eyes from each patient were classified as better or worse eyes. They were divided based on baseline MD values into the following four groups: MD > -3 dB, -6 dB < MD ≤ -3 dB, -12 dB < MD ≤ -6 dB, and MD ≤ -12 dB. The variability of MD during the observation period and the 95% prediction intervals were analyzed. Pointwise variability of limits at each test locations were also calculated.

Results: The numbers of better and worse eyes included in the study were forty-six and thirty-three. The median follow-up period was 1.3 years (range: 0.5 to 1.9 years). The 95% prediction intervals for MD values were ±1.41 dB for better eyes (n = 46) and ±1.47 dB for worse eyes (n = 33). The 95% prediction intervals in the MD > -3 dB, -6 dB < MD ≤ -3 dB, -12 dB < MD ≤ -6 dB, and MD ≤ -12 dB groups were ±1.63 dB, ±1.34 dB, ±1.78 dB, and ±1.33 dB, respectively. Pointwise variability of worse eyes was larger than better eyes especially in between 10 to 15 dB.

Conclusion: In the case of a difference in MD greater than the 95% prediction intervals when compared with the previous visual field result, we should pay much attention to the possibility of progression of the glaucomatous visual field in stable glaucoma patients.