Rodolphe Vallée, Dilsah Körpe, Jean-Noël Vallée, Georgios N Tsiropoulos, Daniela Gallo Castro, Irmela Mantel, Constantin J Pournaras, Aude Ambresin
{"title":"眼前和眼球循环动力学对视网膜毛细血管丛和绒毛膜血管密度的影响。","authors":"Rodolphe Vallée, Dilsah Körpe, Jean-Noël Vallée, Georgios N Tsiropoulos, Daniela Gallo Castro, Irmela Mantel, Constantin J Pournaras, Aude Ambresin","doi":"10.1007/s00417-024-06544-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To highlight the influence of preocular and ocular vascular circulatory dynamics on the vascular density (VD) of retinal capillary plexuses (RCPs) and choriocapillaris (CC) in patients with and without cardiovascular risk (CVR) factors.</p><p><strong>Methods: </strong>A retrospective observational study in patients with and without CVR factors (type 1 and 2 diabetes, arterial hypertension, and hypercholesterolemia). Fluorescein (FA) and indocyanine (ICGA) angiography circulatory times were arterial time (FA<sub>AT</sub>), start (FA<sub>startLF</sub>) and end (FA<sub>endLF</sub>) of laminar flow, and arterial time (ICGA<sub>AT</sub>), respectively. OCT angiography VDs were superficial (VD<sub>SCP</sub>) and deep (VD<sub>DCP</sub>) RCPs and CC (VD<sub>CC</sub>) VDs. Correlation and regression analysis were performed after adjusting for confounding factors.</p><p><strong>Results: </strong>177 eyes of 177 patients (mean age: 65.2 ± 15.9 years, n = 92 with and 85 without CVR) were included. VD<sub>SCP</sub> and VD<sub>DCP</sub> were significantly inversely correlated with FA<sub>AT</sub>, FA<sub>startLF</sub> and FA<sub>endLF</sub> likewise VD<sub>CC</sub> with ICGA<sub>AT</sub>. Correlations were stronger in patients without CVR than with CVR. CVR, FA<sub>AT</sub>, FA<sub>startLF</sub> and FA<sub>endLF</sub> were more strongly correlated with VD<sub>DCP</sub> than VD<sub>SCP</sub>. FA<sub>AT</sub>, FA<sub>startLF</sub> and FA<sub>endLF</sub> significantly impacted VD<sub>SCP</sub> and VD<sub>DCP</sub>, likewise ICGA<sub>AT</sub> impacted VD<sub>DCP</sub>. VD<sub>DCP</sub> was most strongly impacted by FA<sub>AT</sub> and FA<sub>startLF</sub>.</p><p><strong>Conclusion: </strong>Ocular and pre-ocular circulatory dynamics significantly impacted RCPs and CC VDs, especially deep RCP.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":"3867-3879"},"PeriodicalIF":2.4000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608175/pdf/","citationCount":"0","resultStr":"{\"title\":\"Impact of preocular and ocular circulatory dynamics on the vascular density of retinal capillary plexuses and choriocapillaris.\",\"authors\":\"Rodolphe Vallée, Dilsah Körpe, Jean-Noël Vallée, Georgios N Tsiropoulos, Daniela Gallo Castro, Irmela Mantel, Constantin J Pournaras, Aude Ambresin\",\"doi\":\"10.1007/s00417-024-06544-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To highlight the influence of preocular and ocular vascular circulatory dynamics on the vascular density (VD) of retinal capillary plexuses (RCPs) and choriocapillaris (CC) in patients with and without cardiovascular risk (CVR) factors.</p><p><strong>Methods: </strong>A retrospective observational study in patients with and without CVR factors (type 1 and 2 diabetes, arterial hypertension, and hypercholesterolemia). Fluorescein (FA) and indocyanine (ICGA) angiography circulatory times were arterial time (FA<sub>AT</sub>), start (FA<sub>startLF</sub>) and end (FA<sub>endLF</sub>) of laminar flow, and arterial time (ICGA<sub>AT</sub>), respectively. OCT angiography VDs were superficial (VD<sub>SCP</sub>) and deep (VD<sub>DCP</sub>) RCPs and CC (VD<sub>CC</sub>) VDs. Correlation and regression analysis were performed after adjusting for confounding factors.</p><p><strong>Results: </strong>177 eyes of 177 patients (mean age: 65.2 ± 15.9 years, n = 92 with and 85 without CVR) were included. VD<sub>SCP</sub> and VD<sub>DCP</sub> were significantly inversely correlated with FA<sub>AT</sub>, FA<sub>startLF</sub> and FA<sub>endLF</sub> likewise VD<sub>CC</sub> with ICGA<sub>AT</sub>. Correlations were stronger in patients without CVR than with CVR. CVR, FA<sub>AT</sub>, FA<sub>startLF</sub> and FA<sub>endLF</sub> were more strongly correlated with VD<sub>DCP</sub> than VD<sub>SCP</sub>. FA<sub>AT</sub>, FA<sub>startLF</sub> and FA<sub>endLF</sub> significantly impacted VD<sub>SCP</sub> and VD<sub>DCP</sub>, likewise ICGA<sub>AT</sub> impacted VD<sub>DCP</sub>. VD<sub>DCP</sub> was most strongly impacted by FA<sub>AT</sub> and FA<sub>startLF</sub>.</p><p><strong>Conclusion: </strong>Ocular and pre-ocular circulatory dynamics significantly impacted RCPs and CC VDs, especially deep RCP.</p>\",\"PeriodicalId\":12795,\"journal\":{\"name\":\"Graefe’s Archive for Clinical and Experimental Ophthalmology\",\"volume\":\" \",\"pages\":\"3867-3879\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608175/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Graefe’s Archive for Clinical and Experimental Ophthalmology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00417-024-06544-4\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/31 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Graefe’s Archive for Clinical and Experimental Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00417-024-06544-4","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/31 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Impact of preocular and ocular circulatory dynamics on the vascular density of retinal capillary plexuses and choriocapillaris.
Purpose: To highlight the influence of preocular and ocular vascular circulatory dynamics on the vascular density (VD) of retinal capillary plexuses (RCPs) and choriocapillaris (CC) in patients with and without cardiovascular risk (CVR) factors.
Methods: A retrospective observational study in patients with and without CVR factors (type 1 and 2 diabetes, arterial hypertension, and hypercholesterolemia). Fluorescein (FA) and indocyanine (ICGA) angiography circulatory times were arterial time (FAAT), start (FAstartLF) and end (FAendLF) of laminar flow, and arterial time (ICGAAT), respectively. OCT angiography VDs were superficial (VDSCP) and deep (VDDCP) RCPs and CC (VDCC) VDs. Correlation and regression analysis were performed after adjusting for confounding factors.
Results: 177 eyes of 177 patients (mean age: 65.2 ± 15.9 years, n = 92 with and 85 without CVR) were included. VDSCP and VDDCP were significantly inversely correlated with FAAT, FAstartLF and FAendLF likewise VDCC with ICGAAT. Correlations were stronger in patients without CVR than with CVR. CVR, FAAT, FAstartLF and FAendLF were more strongly correlated with VDDCP than VDSCP. FAAT, FAstartLF and FAendLF significantly impacted VDSCP and VDDCP, likewise ICGAAT impacted VDDCP. VDDCP was most strongly impacted by FAAT and FAstartLF.
Conclusion: Ocular and pre-ocular circulatory dynamics significantly impacted RCPs and CC VDs, especially deep RCP.
期刊介绍：
Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.
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