Anita Zia, Mahmood Shams, Ali Dabbagh, Milad Shahsavari, Akbar Dorgalaleh
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引用次数: 0
摘要
癌症相关血栓形成（CAT）是一种常见的并发症，也是活动性癌症患者发病和死亡的主要原因。CAT 常见于各种恶性肿瘤，尤其是胰腺癌、卵巢癌、胃癌、结直肠癌和血液肿瘤。事实上，CAT 是一种复杂的多因素并发症，可能受癌症类型、遗传背景、嗜血栓变异和凝血因子浓度升高的影响。一些研究表明，遗传性血栓嗜性变异（如凝血酶原 20210、因子 V Leiden、因子 XIII Val34Leu、MTHFR C677T）在 CAT 的发生中起着重要作用，而另一些研究则发现它们与 CAT 之间没有相关性。在本综述中，我们试图研究遗传性血栓性疾病在 CAT 发生中可能扮演的角色。
Cancer-associated thrombosis: the role of inherited thrombophilia.
Cancer-associated thrombosis (CAT) is a common complication and a major cause of morbidity and mortality in patients with active cancers. CAT is common in various malignancies, particularly pancreatic, ovarian, gastric, colorectal, and hematologic cancers. In fact, CAT is a complicated multifactorial complication that may be influenced by the type of cancer as well as by the genetic background and inheritance of thrombophilic variants and elevated concentrations of coagulation factors. Several studies have shown the prominent role of inherited thrombophilias, such as prothrombin 20210, factor V Leiden, factor XIII Val34Leu, MTHFR C677T, in the occurrence of CAT, while others have found no correlation between them and CAT. In the present review, we have attempted to investigate the possible role of inherited thrombophilia in the occurrence of CAT.
期刊介绍：
Blood Coagulation & Fibrinolysis is an international fully refereed journal that features review and original research articles on all clinical, laboratory and experimental aspects of haemostasis and thrombosis. The journal is devoted to publishing significant developments worldwide in the field of blood coagulation, fibrinolysis, thrombosis, platelets and the kininogen-kinin system, as well as dealing with those aspects of blood rheology relevant to haemostasis and the effects of drugs on haemostatic components
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