在哥伦比亚东部梅塔省急性热带发热综合征流行病学监测中发现的意外虫媒病毒

IF 4.7 3区 医学 Q1 INFECTIOUS DISEASES
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引用次数: 0

摘要

背景拉丁美洲热带地区常见非特异性急性热带发热疾病(NEATFI)。登革热、基孔肯雅热、寨卡病毒、马雅罗病毒和乌苏图病毒等可在美洲热带地区共存。本研究旨在调查引起哥伦比亚梅塔省患者急性发热综合征的虫媒病毒。研究方法在 2021 年 6 月至 2023 年 2 月期间,在哥伦比亚东部梅塔省的拉诺斯地区开展了一项流行病学监测研究。对登革热、乌苏图、基孔肯雅和马雅罗病毒进行了 ELISA 检测。对乌苏图、登革热、寨卡、马亚罗和奥罗普切虫媒病毒进行了 RT-qPCR 检测。基孔肯雅病毒、马亚罗病毒和乌苏图病毒的血清流行率分别为 41%(28/68)、40%(27/67)和 62%(47/75)。一名患者出现了基孔肯雅病毒血清转换;两名患者出现了玛雅罗病毒血清转换,一名患者出现了乌苏图病毒血清转换。在九名发热患者中检测到了乌苏图病毒的 NS5 基因片段。其余虫媒病毒的 RT-qPCR 检测结果均为阴性。九名乌苏图病毒阳性患者的临床症状与登革热、基孔肯雅病毒、寨卡病毒和马雅洛病毒感染的症状非常相似。由于Usutu感染和Mayaro热具有类似登革热的临床特征,因此应提出一种新的算法来提高急性热带热病的准确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unexpected arboviruses found in an epidemiological surveillance of acute tropical febrile syndrome in the department of Meta, Eastern Colombia

Background

Nonspecific acute tropical febrile illnesses (NEATFI) are common in the Latin American tropics. Dengue, Chikungunya, Zika, Mayaro, and Usutu, among others, can coexist in the American tropics. This study aimed to surveil the arboviruses that cause| acute febrile syndrome in patients in the Meta department, Colombia.

Methods

Between June 2021 and February 2023, an epidemiological surveillance study was conducted in the Llanos of the Meta department in Eastern Colombia.

Results

One hundred patients in the acute phase with typical prodromal symptoms of NEATFI infection who attended the emergency department of the Villavicencio Departmental Hospital were included. ELISA tests were performed for Dengue, Usutu, Chikungunya, and Mayaro. RT-qPCR was performed to detect the arboviruses Usutu, Dengue, Zika, Mayaro, and Oropouche. The seroprevalence for the Chikungunya, Mayaro, and Usutu viruses was 41 % (28/68), 40 % (27/67), and 62 % (47/75), respectively. Seroconversion for Chikungunya was observed in one patient; two seroconverted to Mayaro and one to Usutu. The NS5 gene fragment of the Usutu virus was detected in nine febrile patients. RT-qPCR of the remaining arboviruses was negative. The clinical symptoms of the nine Usutu-positive patients were very similar to those of Dengue, Chikungunya, Zika, and Mayaro infections.

Conclusions

The pervasive detection of unexpected viruses such as Usutu and Mayaro demonstrated the importance of searching for other viruses different from Dengue. Because Usutu infection and Mayaro fever have clinical features like Dengue, a new algorithm should be proposed to improve the accuracy of acute tropical fevers.

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来源期刊
Journal of Infection and Public Health
Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES
CiteScore
13.10
自引率
1.50%
发文量
203
审稿时长
96 days
期刊介绍: The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.
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