锌通过上调 Nrf2/ HO-1/ Nf-κB 信号传导和雄激素受体基因，缓解苯甲酸钠诱导的睾丸功能障碍

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2024-07-26 DOI:10.1016/j.jtemb.2024.127505

Ayodeji Johnson Ajibare , Adeyemi Fatai Odetayo , Olabode Oluwadare Akintoye , Ayotunde Jegede Oladotun , Moses Agbomhere Hamed

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引用次数: 0

摘要

背景苯甲酸钠（SB）广泛用于饮料、果汁、调味汁、油、番茄酱、牙膏、漱口水、化妆品、牙膏和药品等日常用品中。然而，即使在安全剂量范围内，SB 也与性腺毒性有关。另一方面，锌（Zn）已被证明可以改善各种生育指数。因此，本研究旨在探讨锌对 SB 引起的睾丸毒性可能产生的改善作用。方法：将动物随机分为对照组、SB 组、锌组和 SB+Zn 组。所有处理均持续 28 天。结果：SB 处理导致生殖激素水平、精子功能和运动学失调，雄激素受体（ANDR）下调。此外，还观察到睾丸中的 SOD、CAT、GSH、Nrf2 和 HO- 1 活性水平降低，IL-1β、TNF-α、Nf-κB 和 Caspase 3 增加。接触锌的大鼠经 SB 处理后，这些由 SB 引起的扭曲现象得到了改善。结论：我们的研究表明，锌可通过调节 Nrf2/HO-1/ Nf-κB 信号传导和 ANDR 上调来减轻 SB 诱导的睾丸毒性。

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Zinc abates sodium benzoate -induced testicular dysfunction via upregulation of Nrf2/ HO-1/ Nf-κB signaling and androgen receptor gene

Background

Sodium Benzoate (SB) is used in daily products such as drinks, juices, sauces, oils, ketchup, toothpaste, mouthwashes, cosmetics, dentifrices, and pharmaceutical products. However, SB has been implicated in gonadotoxicity even at a dosage within the safe limit. Zinc (Zn), on the other hand, has been shown to improve various fertility indices. Hence, this study was designed to explore the possible ameliorative effect of Zn on SB-induced testicular toxicity. METHODS: Animals were randomly divided into control, SB, Zn, and SB+Zn. All treatment lasted for 28 days. RESULTS: SB treatment caused a derangement in reproductive hormone levels, sperm function, and kinematics and a down-regulation of the Androgen receptor (ANDR). Also, a decrease in testicular levels of SOD, CAT, GSH, Nrf2, and HO- 1 activity and an increase in IL-1β, TNF-α, Nf-κB, and Caspase 3 were observed. These SB-induced distortions were ameliorated in SB-treated rats exposed to Zn. CONCLUSION: Our study suggests that zinc abates SB-induced testicular toxicity by modulating Nrf2/HO-1/ Nf-κB signaling and ANDR upregulation.

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.