结晶:以虚拟模式部署的研究级实验为基础,解决化学工程课堂中的晶体成核问题

IF 3.5 2区 教育学 Q1 EDUCATION, SCIENTIFIC DISCIPLINES
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引用次数: 0

摘要

通过成核结晶可以从原液中分离出活性药物成分。虽然化学工程教科书提供了有关结晶和成核理论的理论知识,但往往无法提供有关成核机制的实际见解。为了弥补这一不足,我们在化学工程二年级课堂上引入了虚拟成核实验。主要目的是向学生传授研究和加工工业中的结晶程序,教他们如何分析和管理收集的数据,同时将理论知识融会贯通。这包括传达可从结晶过程中获得的信息类型,以及指导学生如何根据所学理论分析和管理收集到的数据。我们设计了一个关于成核的原创化学工程问题,该问题直接来自课堂上从虚拟实验中收集的原始数据。这种方法不同于解决标准课本问题的传统方法。令人遗憾的是,教科书上的问题往往缺乏关于如何从原始数据中直接获得成核率或表面自由能的关键信息。虚拟实验结束后,学生对结晶的实践和理论方面都有了全面的了解,尤其是对成核的了解。本研究中阐明的方法可应用于各种化学工程模块,包括过程工程、化学工程中的单元操作、传质,甚至可以整合到专门的结晶课程中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Crystallisation: Solving crystal nucleation problem in the chemical engineering classroom based on the research grade experiments deployed in virtual mode

Crystallization via nucleation can isolate active pharmaceutical ingredients from their crudes. While chemical engineering textbooks provide theoretical knowledge on crystallization and nucleation theories, they often fall short in providing provide practical insights on the nucleation mechanism. To bridge this gap, we introduced a virtual experiment on nucleation in second-year chemical engineering classrooms. The main goal is to educate students on crystallization procedures in research and process industries, teaching them how to analyse and manage collected data while integrating theoretical knowledge. This includes conveying the kind of information that can be obtained from a crystallisation process and instructing students on how to analyse and manage the data collected in the light of the theories learned. We devised an original chemical engineering problem on nucleation, derived directly from the raw data collected in the classroom from virtual experiments. This method differs from the conventional approach of solving standard textbook problems. The textbook problems, regrettably often lack crucial information on how nucleation rate or surface free energy are directly obtained from raw data. By the conclusion of the virtual experiment, students have acquired a comprehensive understanding encompassing both practical and theoretical aspects of crystallization, with a particular focus on nucleation. The methodologies elucidated in this study can be applied across a spectrum of chemical engineering modules, including process engineering, unit operations in chemical engineering, mass transfer, and can even be integrated into specialized courses dedicated to crystallization.

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来源期刊
CiteScore
8.80
自引率
17.90%
发文量
30
审稿时长
31 days
期刊介绍: Education for Chemical Engineers was launched in 2006 with a remit to publisheducation research papers, resource reviews and teaching and learning notes. ECE is targeted at chemical engineering academics and educators, discussing the ongoingchanges and development in chemical engineering education. This international title publishes papers from around the world, creating a global network of chemical engineering academics. Papers demonstrating how educational research results can be applied to chemical engineering education are particularly welcome, as are the accounts of research work that brings new perspectives to established principles, highlighting unsolved problems or indicating direction for future research relevant to chemical engineering education. Core topic areas: -Assessment- Accreditation- Curriculum development and transformation- Design- Diversity- Distance education-- E-learning Entrepreneurship programs- Industry-academic linkages- Benchmarking- Lifelong learning- Multidisciplinary programs- Outreach from kindergarten to high school programs- Student recruitment and retention and transition programs- New technology- Problem-based learning- Social responsibility and professionalism- Teamwork- Web-based learning
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