姜黄素单独使用而非与胡椒碱结合使用，可通过增加胰高血糖素样肽-1 受体信号转导和其他特性，对压力超负荷大鼠发挥心脏保护作用

IF 3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional and Complementary Medicine Pub Date : 2025-09-01 DOI:10.1016/j.jtcme.2024.07.007

Xiao-jie Bai , Jun-tao Hao , Qi-long Feng , Chen-meng Guo , Min Pang , Jia Li , Jin Wang , Jian-feng Xing

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引用次数: 0

摘要

背景和姜黄素已显示出显著的心血管保护作用。然而，低生物利用度限制了其实际应用。作为一种天然的生物增强剂，胡椒碱有望提高姜黄素的生物利用度，从而增强其有益作用。同时，胰高血糖素样肽-1受体（glucagon-like peptide-1 receptor, GLP-1R）信号已被证实参与心血管事件的调控。本研究旨在探讨胡椒碱是否能增强压力过载大鼠姜黄素的有益作用，GLP-1/GLP-1R信号通路是否参与其作用机制。方法与结果SD成年大鼠经腹主动脉缩窄术（AAC）治疗至16周后血压升高，心肌肥厚。从AAC手术后第17周开始，口服姜黄素（100 mg/kg/天）或/和胡椒碱（20 mg/kg/天）4周。姜黄素单独治疗可显著降低血压，改善心血管重塑，改善左心室功能和内皮依赖性血管松弛。在这些结果的同时，心肌中GLP-1R的表达上调。单独使用胡椒碱也表现出一定的正性肌力心脏活动，但效果不太显著。与姜黄素相比，姜黄素与胡椒碱联用对心血管的保护作用没有增强，空腹血清GLP-1水平和心肌GLP-1R表达均有降低。结论姜黄素通过上调GLP-1R对压力过载大鼠的心血管有保护作用，抑制GLP-1/GLP-1R信号通路可能与姜黄素与胡椒碱联用的有益作用有限有关。本研究提供了一种新的思路，即口服一些香料可能通过调节GLP-1/GLP-1R系统在肠-心轴调节模式下影响心血管功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Curcumin alone not combined with piperine exerts cardioprotective effects in pressure-overload rats by increasing glucagon-like peptide-1 receptor signaling and additional properties

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Curcumin alone not combined with piperine exerts cardioprotective effects in pressure-overload rats by increasing glucagon-like peptide-1 receptor signaling and additional properties

Background and aim

Curcumin has shown significant cardiovascular protective effects. However, the low bioavailability limits its practical application. As a natural bioenhancer, piperine is expected to increase the bioavailability of curcumin, and then, enhance its beneficial effects. Meanwhile, glucagon-like peptide-1 receptor (GLP-1R) signaling has been confirmed to be involved in the regulation of cardiovascular events. Herein, this study aimed to investigate whether piperine could enhance the beneficial effects of curcumin in pressure-overload rats and whether GLP-1/GLP-1R signaling is involved in their action mechanism.

Methods and results

Male Sprague-Dawley (SD) adult rats were subjected to abdominal aortic constriction (AAC) surgery to 16 weeks, which elevated blood pressure and induced cardiac hypertrophy. Curcumin (100 mg/kg/day) or/and piperine (20 mg/kg/day) were orally given for 4 weeks from the 17th week after AAC surgery. Curcumin alone treatment significantly lowered blood pressure, ameliorated cardiovascular remodeling, improved left ventricular performance and endothelium-dependent vascular relaxation. Accompanied by these results, GLP-1R expression in the myocardium was up-regulated. Piperine alone also exhibited a certain positive inotropic cardiac activity, but the effect was less significant. The combination of curcumin and piperine didn't show enhanced cardiovascular protective effects relative to curcumin, along with decreased fasting serum GLP-1 level and GLP-1R expression in the myocardium.

Conclusion

Curcumin exerts cardiovascular protective effects in pressure-overload rats by upregulating GLP-1R, and inhibiting of GLP-1/GLP-1R signaling pathway may be related to the limited beneficial effects of combination of curcumin and piperine. This study provides a new thinking that oral administration of some spices may affect cardiovascular function by modulating the GLP-1/GLP-1R system in a mode of gut-heart axis regulation.

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来源期刊

Journal of Traditional and Complementary Medicine Medicine-Complementary and Alternative Medicine

CiteScore

9.30

自引率

6.70%

发文量

审稿时长

66 days

期刊介绍： eJTCM is committed to publish research providing the biological and clinical grounds for using Traditional and Complementary Medical treatments as well as studies that demonstrate the pathophysiological and molecular/biochemical bases supporting the effectiveness of such treatments. Review articles are by invitation only. eJTCM is receiving an increasing amount of submission, and we need to adopt more stringent criteria to select the articles that can be considered for peer review. Note that eJTCM is striving to increase the quality and medical relevance of the publications.