Libby Wei MD , Taylor Kolosky , Sarah Byun , Alexandra S. Dolgetta MD , Moran R. Levin MD , Jana A. Friedman MD , Monica M. Manrique MD , Isabelle Dortonne MD , Camilo Martinez COA , Marlet Bazemore MD , Mohamad S. Jaafar MD , William P. Madigan MD , Laurence Magder PhD , Janet L. Alexander MD, MS
{"title":"婴幼儿白内障患者的晶状体厚度","authors":"Libby Wei MD , Taylor Kolosky , Sarah Byun , Alexandra S. Dolgetta MD , Moran R. Levin MD , Jana A. Friedman MD , Monica M. Manrique MD , Isabelle Dortonne MD , Camilo Martinez COA , Marlet Bazemore MD , Mohamad S. Jaafar MD , William P. Madigan MD , Laurence Magder PhD , Janet L. Alexander MD, MS","doi":"10.1016/j.xops.2024.100588","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>The purpose of this study was to determine the association between lens thickness and cataract in participants aged 0 to 5 years.</p></div><div><h3>Design</h3><p>This was a prospective, multicenter, case–control study.</p></div><div><h3>Participants</h3><p>We enrolled 118 participants (171 eyes) aged 0 to 5 years, mean age 14.6 ± 17.0 months, range 0 to 60 months.</p></div><div><h3>Methods</h3><p>Lens thickness was measured on 342 ultrasound biomicroscopy (UBM) images.</p></div><div><h3>Main Outcome Measures</h3><p>Lens thickness; feasibility of lens thickness measurement from UBM images.</p></div><div><h3>Results</h3><p>The mean lens thickness among noncataracts was 3.60 ± 0.17 mm, compared with 3.16 ± 0.61 mm among cataracts (<em>P</em> < 0.0001). Lens thickness <3.5 mm was significantly associated with increased odds of cataract; adjusted odds ratio = 5.99 (95% confidence interval, 2.41–14.88; <em>P</em> < 0.0003) among participants age 0 to 7 months. Lens thickness was significantly associated with cataract laterality among participants age 0 to 7 months (<em>P</em> < 0.0001).</p></div><div><h3>Conclusions</h3><p>Quantitative UBM can be used to evaluate lens thickness in infants and children with congenital cataracts. The lens in congenital cataract eyes was thinner than that of controls among infants. Abnormal lens thickness was significantly associated with cataract. Future longitudinal studies will examine the association between lens thickness and postcataract surgery outcomes.</p></div><div><h3>Financial Disclosure(s)</h3><p>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p></div>","PeriodicalId":74363,"journal":{"name":"Ophthalmology science","volume":"5 1","pages":"Article 100588"},"PeriodicalIF":3.2000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666914524001246/pdfft?md5=d926594c5f4edb7fbd5f74572e84042f&pid=1-s2.0-S2666914524001246-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Lens Thickness in Infants and Children with Cataracts\",\"authors\":\"Libby Wei MD , Taylor Kolosky , Sarah Byun , Alexandra S. Dolgetta MD , Moran R. Levin MD , Jana A. Friedman MD , Monica M. Manrique MD , Isabelle Dortonne MD , Camilo Martinez COA , Marlet Bazemore MD , Mohamad S. Jaafar MD , William P. Madigan MD , Laurence Magder PhD , Janet L. Alexander MD, MS\",\"doi\":\"10.1016/j.xops.2024.100588\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>The purpose of this study was to determine the association between lens thickness and cataract in participants aged 0 to 5 years.</p></div><div><h3>Design</h3><p>This was a prospective, multicenter, case–control study.</p></div><div><h3>Participants</h3><p>We enrolled 118 participants (171 eyes) aged 0 to 5 years, mean age 14.6 ± 17.0 months, range 0 to 60 months.</p></div><div><h3>Methods</h3><p>Lens thickness was measured on 342 ultrasound biomicroscopy (UBM) images.</p></div><div><h3>Main Outcome Measures</h3><p>Lens thickness; feasibility of lens thickness measurement from UBM images.</p></div><div><h3>Results</h3><p>The mean lens thickness among noncataracts was 3.60 ± 0.17 mm, compared with 3.16 ± 0.61 mm among cataracts (<em>P</em> < 0.0001). Lens thickness <3.5 mm was significantly associated with increased odds of cataract; adjusted odds ratio = 5.99 (95% confidence interval, 2.41–14.88; <em>P</em> < 0.0003) among participants age 0 to 7 months. Lens thickness was significantly associated with cataract laterality among participants age 0 to 7 months (<em>P</em> < 0.0001).</p></div><div><h3>Conclusions</h3><p>Quantitative UBM can be used to evaluate lens thickness in infants and children with congenital cataracts. The lens in congenital cataract eyes was thinner than that of controls among infants. Abnormal lens thickness was significantly associated with cataract. Future longitudinal studies will examine the association between lens thickness and postcataract surgery outcomes.</p></div><div><h3>Financial Disclosure(s)</h3><p>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p></div>\",\"PeriodicalId\":74363,\"journal\":{\"name\":\"Ophthalmology science\",\"volume\":\"5 1\",\"pages\":\"Article 100588\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-07-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666914524001246/pdfft?md5=d926594c5f4edb7fbd5f74572e84042f&pid=1-s2.0-S2666914524001246-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ophthalmology science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666914524001246\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmology science","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666914524001246","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Lens Thickness in Infants and Children with Cataracts
Purpose
The purpose of this study was to determine the association between lens thickness and cataract in participants aged 0 to 5 years.
Design
This was a prospective, multicenter, case–control study.
Participants
We enrolled 118 participants (171 eyes) aged 0 to 5 years, mean age 14.6 ± 17.0 months, range 0 to 60 months.
Methods
Lens thickness was measured on 342 ultrasound biomicroscopy (UBM) images.
Main Outcome Measures
Lens thickness; feasibility of lens thickness measurement from UBM images.
Results
The mean lens thickness among noncataracts was 3.60 ± 0.17 mm, compared with 3.16 ± 0.61 mm among cataracts (P < 0.0001). Lens thickness <3.5 mm was significantly associated with increased odds of cataract; adjusted odds ratio = 5.99 (95% confidence interval, 2.41–14.88; P < 0.0003) among participants age 0 to 7 months. Lens thickness was significantly associated with cataract laterality among participants age 0 to 7 months (P < 0.0001).
Conclusions
Quantitative UBM can be used to evaluate lens thickness in infants and children with congenital cataracts. The lens in congenital cataract eyes was thinner than that of controls among infants. Abnormal lens thickness was significantly associated with cataract. Future longitudinal studies will examine the association between lens thickness and postcataract surgery outcomes.
Financial Disclosure(s)
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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