B 细胞表位图谱：通往更好的疫苗和治疗性抗体之路

IF 2.8 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. General subjects Pub Date : 2024-07-28 DOI:10.1016/j.bbagen.2024.130674

Asha Joanne De Leon , M. Christian Tjiam , Yu Yu

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引用次数: 0

摘要

B 细胞表位图谱是一种可以确定和描述 B 细胞受体和分泌抗体的特定抗原结合位点的方法。确定 B 细胞克隆结合的氨基酸抗原群的能力提供了前所未有的细节，有助于开发新型有效的疫苗靶点和治疗各种疾病的抗体。在此，我们将讨论用于绘制 B 细胞表位图的传统方法和新兴技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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B cell epitope mapping: The journey to better vaccines and therapeutic antibodies

B-cell epitope mapping is an approach that can identify and characterise specific antigen binding sites of B-cell receptors and secreted antibodies. The ability to determine the antigenic clusters of amino acids bound by B-cell clones provides unprecedented detail that will aid in developing novel and effective vaccine targets and therapeutic antibodies for various diseases. Here, we discuss conventional approaches and emerging techniques that are used to map B-cell epitopes.

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来源期刊

Biochimica et biophysica acta. General subjects 生物-生化与分子生物学

CiteScore

6.40

自引率

0.00%

发文量

139

审稿时长

30 days

期刊介绍： BBA General Subjects accepts for submission either original, hypothesis-driven studies or reviews covering subjects in biochemistry and biophysics that are considered to have general interest for a wide audience. Manuscripts with interdisciplinary approaches are especially encouraged.