TRPC1：海马的管家

IF 4.3 2区生物学 Q2 CELL BIOLOGY

Cell calcium Pub Date : 2024-07-27 DOI:10.1016/j.ceca.2024.102933

Julia Skerjanz , Lena Bauernhofer , Kerstin Lenk , Anita Emmerstorfer-Augustin , Gerd Leitinger , Florian Reichmann , Thomas Stockner , Klaus Groschner , Oleksandra Tiapko

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引用次数: 0

摘要

非选择性阳离子通道 TRPC1 在大脑中高度表达。最新研究表明，神经元 TRPC1 与 TRPC4 和 TRPC5 形成异构复合物，一小部分作为同构复合物存在，主要存在于 ER 中。鉴于大多数研究都集中于异构 TRPC1/4/5 复合物的作用，因此研究同构 TRPC1 在维持大脑稳态中的特殊作用至关重要。这篇综述重点介绍了有关大脑中 TRPC1 的最新发现，重点是海马体，并汇编了有关 TRPC1/4/5 亚家族中调节剂及其结合位点的最新数据，以激发有关更具选择性的 TRPC1 配体的新研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

TRPC1: The housekeeper of the hippocampus

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TRPC1: The housekeeper of the hippocampus

The non-selective cation channel TRPC1 is highly expressed in the brain. Recent research shows that neuronal TRPC1 forms heteromeric complexes with TRPC4 and TRPC5, with a small portion existing as homotetramers, primarily in the ER. Given that most studies have focused on the role of heteromeric TRPC1/4/5 complexes, it is crucial to investigate the specific role of homomeric TRPC1 in maintaining brain homeostasis. This review highlights recent findings on TRPC1 in the brain, with a focus on the hippocampus, and compiles the latest data on modulators and their binding sites within the TRPC1/4/5 subfamily to stimulate new research on more selective TRPC1 ligands.

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来源期刊

Cell calcium 生物-细胞生物学

CiteScore

8.70

自引率

5.00%

发文量

115

审稿时长

35 days

期刊介绍： Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes