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引用次数: 0
摘要
磁活性水凝胶（MAHs）由掺有磁性颗粒的聚合物网络组成，这些磁性颗粒能使材料对磁刺激做出机械反应。这种多功能性可远程动态调节机械特性。这些特性与水凝胶的生物相容性相结合，使 MAHs 成为药物输送和生物支架的绝佳材料。在这项工作中，利用人体血浆（∼20 Pa）制成了具有强磁致伸缩性的超软生物 MAH。我们使用一种新型内部设备对该材料进行了实验测试，该设备可精确控制磁致动条件，从而在机械变形和刚度方面对水凝胶进行调节。我们研究了磁驱动对聚合物网络内溶剂排出和扩散动力学的影响。为了进一步阐明溶剂扩散过程的驱动机制，我们提出了一个计算框架，用于模拟磁响应材料中两种不同物质的扩散过程。这些实验和计算成果为超软 MAH 在生物工程中的应用带来了令人兴奋的新机遇。
Magneto-mechanically derived diffusion processes in ultra-soft biological hydrogels
Magneto-active hydrogels (MAHs) consist of a polymeric network doped with magnetic particles that enable the material to mechanically respond to magnetic stimuli. This multifunctionality allows for modulation of mechanical properties in a remote and dynamic manner. These characteristics combined with the biocompatibility of hydrogels, make MAHs excellent for drug delivery and biological scaffolds. In this work, ultra-soft biological MAHs with strong magnetostriction are fabricated from human blood plasma (20 Pa). The material is experimentally tested using a novel in-house device that allows for a precise control of magnetic actuation conditions, enabling the hydrogel modulation in terms of mechanical deformation and stiffness. We study the impact of magnetic actuation on the solvent expulsion and diffusion dynamics within the polymeric network. To further elucidate the mechanisms driving solvent diffusion processes, a computational framework for modeling the diffusion process of two different species within a magneto-responsive material is proposed. These experimental and computational outcomes open exciting new opportunities for the use of ultra-soft MAHs in bioengineering applications.
期刊介绍：
The aim of Journal of The Mechanics and Physics of Solids is to publish research of the highest quality and of lasting significance on the mechanics of solids. The scope is broad, from fundamental concepts in mechanics to the analysis of novel phenomena and applications. Solids are interpreted broadly to include both hard and soft materials as well as natural and synthetic structures. The approach can be theoretical, experimental or computational.This research activity sits within engineering science and the allied areas of applied mathematics, materials science, bio-mechanics, applied physics, and geophysics.
The Journal was founded in 1952 by Rodney Hill, who was its Editor-in-Chief until 1968. The topics of interest to the Journal evolve with developments in the subject but its basic ethos remains the same: to publish research of the highest quality relating to the mechanics of solids. Thus, emphasis is placed on the development of fundamental concepts of mechanics and novel applications of these concepts based on theoretical, experimental or computational approaches, drawing upon the various branches of engineering science and the allied areas within applied mathematics, materials science, structural engineering, applied physics, and geophysics.
The main purpose of the Journal is to foster scientific understanding of the processes of deformation and mechanical failure of all solid materials, both technological and natural, and the connections between these processes and their underlying physical mechanisms. In this sense, the content of the Journal should reflect the current state of the discipline in analysis, experimental observation, and numerical simulation. In the interest of achieving this goal, authors are encouraged to consider the significance of their contributions for the field of mechanics and the implications of their results, in addition to describing the details of their work.
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