吸入氧气对产后出血的影响：系统回顾与元分析

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-01 DOI:10.4103/ijnmr.ijnmr_118_23

Elaheh Mansourie Ghezelhesari, Sedigheh Abdollahpour, Seyed Javad Hosseini, Bibi Leila Hoseini, Atefeh Yas, Ezat Hajmolarezaei, T. Khadivzadeh

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引用次数: 0

摘要

产后出血（PPH）是一个严重的问题，会增加产妇死亡的风险。以往的研究调查了吸入氧气（IO）对 PPH 的影响。他们发现了一些相互矛盾的结果。因此，本系统综述和荟萃分析旨在确定 IO 对 PPH 的影响。截至 2022 年 11 月底，根据 PRISMA 框架在 Web of Science、PubMed、Scopus 和 Cochrane Library 数据库中对随机试验进行了检索。统计分析在 STATA v. 14 软件中进行。采用 I2 统计量评估研究之间的异质性。应用随机效应模型、样本量以及各组的平均值和标准差来报告汇总效应大小。科克伦随机试验偏倚风险工具（RoB 2）第 2 版用于评估纳入研究的偏倚风险。最后，有五篇文章被纳入荟萃分析。分别有两篇和三篇研究报告了在一小时和两小时氧疗期间阴道分娩后出血的平均值。结果显示，与常规护理相比，干预组的 IO 能明显减少阴道分娩后出血 38.91 毫升（WMD：-38.91，95%CI：-60.18 至 -17.64）。此外，干预组在 1 小时（WMD：-38.42，95%CI：-71.62 至-5.22）和 2 小时（WMD：-41.93，95%CI：-60.15 至-23.71）内进行 IO 可显著减少出血量。根据本研究，与常规护理相比，IO 能明显减少干预组的 PPH。然而，要更好地确定这一问题，还需要更严格的随机临床试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Effect of Inhaled Oxygen on Postpartum Hemorrhage: A Systematic Review and Meta-Analysis

Postpartum Hemorrhage (PPH) is a significant problem that can increase the risk of maternal mortality. Previous studies investigated the effect of Inhaled Oxygen (IO) on PPH. They found some conflicting results. Thus, the current systematic review and meta-analysis aimed to determine the effect of IO on PPH. Randomized trials were searched according to the PRISMA framework until the end of November 2022 in Web of Science, PubMed, Scopus, and Cochrane Library databases. Statistical analyses were performed in the STATA v. 14 software. I2 statistic was applied to assess heterogeneity between studies. The random effect model, sample size, and mean and standard deviation of each group were applied to report the pooled effect size. Version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2) was used to evaluate the risk of bias in the included studies. Finally, five articles were included in the meta-analysis. Two and three studies reported the mean of bleeding after vaginal delivery during one- and two-hours oxygen therapy, respectively. Results showed that IO significantly reduced bleeding by 38.91 mL in the intervention group compared to routine care (WMD: −38.91, 95%CI: −60.18 to −17.64) after vaginal delivery. In addition, IO during one (WMD: −38.42, 95%CI: −71.62 to −5.22) and two (WMD: −41.93, 95%CI: −60.15 to − 23.71) hours significantly decreased bleeding in the intervention. According to the present study, IO can significantly reduce PPH in the intervention group compared to routine care. However, more rigorously randomized clinical trials are required to decide better about this issue.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.