{"title":"一名高危 MDS 老年患者的微移植：病例报告和文献综述","authors":"Kangli Wu, Mingsuo Liu, Yajun Wu, Qiulian Luo, Jin Chen, Wanling Xu, Xixi Yang, Piaoru Hong, Zhigang Qu","doi":"10.1016/j.lrr.2024.100475","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>The prognosis of patients with myelodysplastic syndromes (MDS) (very high risk) is poor.HLA-mismatched allogeneic T-cell infusion which is called micro-transplantation can not only shorten the time of bone marrow suppression, but also improve the treatment response of patients.</p></div><div><h3>Case presentation</h3><p>A 74-year-old woman presented with fatigue and showed pancytopenia on routine blood count. She was diagnosed with MDS (very high risk) after bone marrow examination,then she received 4 cycles of micro-transplantation. The progression-free survival was 22 months and overall survival was 33 months.</p></div><div><h3>Discussion</h3><p>The patient showed good tolerance to micro-transplantation with manageable toxicities and short myelosuppression time.</p></div>","PeriodicalId":38435,"journal":{"name":"Leukemia Research Reports","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213048924000657/pdfft?md5=cce42c4b377861e7392c209e22d0247a&pid=1-s2.0-S2213048924000657-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Micro-transplantation in an elderly patient with very high risk MDS:A case report and literature review\",\"authors\":\"Kangli Wu, Mingsuo Liu, Yajun Wu, Qiulian Luo, Jin Chen, Wanling Xu, Xixi Yang, Piaoru Hong, Zhigang Qu\",\"doi\":\"10.1016/j.lrr.2024.100475\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>The prognosis of patients with myelodysplastic syndromes (MDS) (very high risk) is poor.HLA-mismatched allogeneic T-cell infusion which is called micro-transplantation can not only shorten the time of bone marrow suppression, but also improve the treatment response of patients.</p></div><div><h3>Case presentation</h3><p>A 74-year-old woman presented with fatigue and showed pancytopenia on routine blood count. She was diagnosed with MDS (very high risk) after bone marrow examination,then she received 4 cycles of micro-transplantation. The progression-free survival was 22 months and overall survival was 33 months.</p></div><div><h3>Discussion</h3><p>The patient showed good tolerance to micro-transplantation with manageable toxicities and short myelosuppression time.</p></div>\",\"PeriodicalId\":38435,\"journal\":{\"name\":\"Leukemia Research Reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2213048924000657/pdfft?md5=cce42c4b377861e7392c209e22d0247a&pid=1-s2.0-S2213048924000657-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Leukemia Research Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213048924000657\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Leukemia Research Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213048924000657","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"HEMATOLOGY","Score":null,"Total":0}
Micro-transplantation in an elderly patient with very high risk MDS:A case report and literature review
Introduction
The prognosis of patients with myelodysplastic syndromes (MDS) (very high risk) is poor.HLA-mismatched allogeneic T-cell infusion which is called micro-transplantation can not only shorten the time of bone marrow suppression, but also improve the treatment response of patients.
Case presentation
A 74-year-old woman presented with fatigue and showed pancytopenia on routine blood count. She was diagnosed with MDS (very high risk) after bone marrow examination,then she received 4 cycles of micro-transplantation. The progression-free survival was 22 months and overall survival was 33 months.
Discussion
The patient showed good tolerance to micro-transplantation with manageable toxicities and short myelosuppression time.
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