COVID-19 大流行如何影响人道主义紧急情况下的抗生素消费?五种人道主义情况下的结果。

IF 1.8 Q3 INFECTIOUS DISEASES
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引用次数: 0

摘要

导言在COVID-19大流行的最初几个月中,高收入国家和低收入国家都报告称COVID-19患者的抗生素消耗量有所增加。无国界医生组织(MSF)收集了2018-2021年在以下人道主义环境中的数据:阿富汗(拉什卡尔加)、孟加拉国(库图帕隆)、印度(拉什卡尔加):阿富汗(拉什卡尔加)、孟加拉国(库图帕隆)、刚果民主共和国(姆韦索和巴拉卡)和南苏丹(本提乌)。根据世界卫生组织(WHO)药物统计合作中心的方法,住院病人和门诊病人的抗生素消耗量按每千人每日定义剂量(DDD)计算。采用自回归综合移动平均(ARIMA)模型进行间断时间序列(ITS)分析,对每月抗生素消耗量进行回顾性分析。结果COVID-19大流行对南苏丹(本提乌)和孟加拉国(库图帕隆)的抗生素总消耗量没有显著的统计学影响。同样,大流行对刚果民主共和国(巴拉卡)的抗生素总消费量也没有影响,尽管在 2020 年 3 月,在获取组抗生素的推动下,抗生素总消费量最初增加了 0.27%(估计值=0.274,P 值=0.006)。同时,刚果(金)和阿富汗(拉什卡尔加)的抗生素总消费量在 COVID-19 大流行时分别下降了 0.74%(估计值=-.744,P=0.003)和 0.26%(估计值=-.26,P< 0.001)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
How did the COVID-19 pandemic affect antibiotic consumption within humanitarian emergencies? Results from five humanitarian contexts

Introduction

Both high- and low-income countries reported increased antibiotic consumption among COVID-19 patients during the first months of the pandemic. To date, however, no studies have examined changes in antibiotic consumption during the COVID-19 pandemic within humanitarian emergency contexts.

Method

Data was collected by Médecins Sans Frontières (MSF) for the years 2018–2021 across the following humanitarian settings: Afghanistan (Lashkar Gah), Bangladesh (Kutupalong), the Democratic Republic of Congo (Mweso and Baraka), and South Sudan (Bentiu). Inpatient and outpatient antibiotic consumption was calculated as Daily Defined Dose (DDD) per 1000 inhabitants per day, as per the World Health Organisation's (WHO) Collaborating Centre for Drug Statistics Methodology. Interrupted time series (ITS) analysis, using an autoregressive integrated moving average (ARIMA) model was used to analyse retrospective monthly antibiotic consumption. The impact of COVID-19 pandemic was evaluated as total antibiotic consumption and according to WHO Access, Watch, Reserve (AWaRe) group classifications within each humanitarian setting.

Results

The COVID-19 pandemic had no statistically significant impact on total antibiotic consumption in South Sudan (Bentiu) and Bangladesh (Kutupalong). Similarly, the pandemic had no impact on total antibiotic consumption in DR Congo (Baraka), despite an initial 0.27% (estimate=.274, p-value=0.006) increase in March 2020 driven by Access group antibiotics. Meanwhile, total antibiotic consumption in DR Congo (Mweso) and Afghanistan (Lashkar Gah) declined by 0.74% (estimate = −.744, p = 0.003) and 0.26% (estimate = −.26, p < 0.001), respectively with the COVID-19 pandemic.

Conclusion

Further studies are required to investigate what may have contributed to these results.

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来源期刊
Infection Prevention in Practice
Infection Prevention in Practice Medicine-Public Health, Environmental and Occupational Health
CiteScore
4.80
自引率
0.00%
发文量
58
审稿时长
61 days
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