EFFECT OF VERONIAAMYGDALINA ON THE ACTIVITIES OF HEPATIC ENZYMES IN WISTAR ALBINO RAT FED WITH CRUDE OIL CONTAMINATED DIET

The present study was carried out to determine the effect of Veroniaamygdalina on the liver of rats fed with crude oil contaminated diet. Preliminary toxicity study was carried out to determine the concentration of bitter leaf and crude oil that could cause toxicity and was carried out using 24. healthy male albino rats that were grouped into 6 of 4 each: Group A animals were the control group fed with just 100g of feed and Group B animals were fed with 100g of feed and 5g of biter leaf; while group C were fed 100g of feed and 10g of bitter leaf, group D were fed 100g of feed 5g of bitter leaf and4ml of crude oil, group B were fed with 100 of feed 10g of bitter leaf and 4ml of crude oil and group F were fed with 100g of feed and 4ml of crude oil. All the plasma liver biomarker enzymesAST, ALT, ALP and ACP were significantly increased (P<0.05) in all the grouped rats i.e. group B to group F compared to the group A rats which were the ‘control but elevated levels of the liver biomarker enzymes were noticed in the group F rats fed with just crude oil contaminated diet. This is an indication of impaired liver function. Aggressiveness, loss of body hairs and weight was also noticed which are clear indications of toxicity.