锥束计算机断层扫描引导下的经导管动脉化疗栓塞术对肝细胞癌生存的疗效：系统性综述

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-17 DOI:10.25259/jcis_32_2024

Levent Akman Solim, Duygu Atasoy, T. Vogl

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引用次数: 0

摘要

锥形束计算机断层扫描（CBCT）引导下的经导管动脉化疗栓塞术（TACE）是晚期肝细胞癌（HCC）患者的另一种治疗选择，但目前仍缺乏对 CBCT 引导下该手术的全面评估以及 CBCT 对患者生存期的影响。我们旨在评估 CBCT 引导下的 TACE 在改善 HCC 患者生存预后方面的疗效和益处，并展示 CBCT 在介入放射学中的重要性。我们进行了荟萃分析，以评估 CBCT 引导的 TACE 与传统 TACE 在治疗 HCC 方面的比较。我们在 PubMed 和 Cochrane 图书馆数据库中检索了已发表的研究。研究结果包括1年或3年局部无进展生存率（LPFS）、总生存率（OS）和肿瘤反应结果。荟萃分析共纳入了 8 项研究，包括 1176 名患者。分析结果显示，与传统 TACE 相比，CBCT 引导的 TACE 可改善 1 年 LPFS（几率比 [OR] = 2.81，P < 0.001）、3 年（OR = 4.42，P = 0.002）和 3 年 OS 率（OR = 3.03，置信区间 = 1.65-11.80，P = 0.14）。CBCT引导下的TACE提高了HCC患者的生存预后；我们的研究填补了这一研究空白，通过对现有证据进行有力的综合，鼓励临床医生和研究人员追求这一医疗技术。

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The efficacy of cone-beam computed tomography-guided transcatheter arterial chemoembolization in hepatocellular carcinoma survival: A systematic review

Cone-beam computed tomography (CBCT)-guided transcatheter arterial chemoembolization (TACE) represents an alternative treatment option for advanced hepatocellular carcinoma (HCC) patients, yet a comprehensive evaluation of CBCT guidance on this procedure and CBCT’s impact on patient survival remains lacking. We aimed to assess the efficacy and benefits of CBCT-guided TACE in improving survival outcomes for patients with HCC and show the importance of CBCT in interventional radiology. Meta-analysis was conducted to evaluate CBCT-guided TACE compared to conventional TACE in the treatment of HCC. PubMed and Cochrane library databases were searched for studies published. Outcomes of interest included 1- or 3-year local progression-free survival (LPFS) rates, overall survival (OS) rates, and tumor response results. A total of eight studies were included in the meta-analysis, comprising 1176 patients. The analysis showed that CBCT-guided TACE improved 1-year LPFS (odds ratio [OR] = 2.81, P < 0.001), 3-year (OR = 4.42, P = 0.002), and the 3-year OS rates (OR = 3.03, Confidence Interval = 1.65–11.80, P = 0.14) compared to conventional TACE. CBCT-guided TACE enhances survival outcomes for patients with HCC; by addressing this research gap, our study endeavors to encourage clinicians and researchers to pursue this medical technology by providing a robust synthesis of current evidence.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.