{"title":"左撇子语言生成和空间注意力侧向化背后的半球内白质不对称和半球间联系","authors":"Miaomiao Zhu, Xiao Wang, Xier Zhao, Qing Cai","doi":"10.1162/nol_a_00153","DOIUrl":null,"url":null,"abstract":"\n Leftward language production and rightward spatial attention are salient features of functional organization in most humans, but their anatomical basis remains unclear. Interhemispheric connections and intra-hemispheric white matter asymmetries have been proposed as important factors underlying functional lateralization. To investigate the role of white matter connectivity in functional lateralization, we first identified 96 left-handers using visual half-field naming tasks. They were then divided into atypical and typical functional dominance based on the lateralization of brain activation in a word generation task (for language production) and a landmark task (for spatial attention). Using a novel fixel-based framework, we obtained fiber-specific properties of white matter pathways. Results showed that 1) differences between two language dominance groups occurred in the asymmetry of the superior longitudinal fasciculus-III (SLF-III), whereas differences between two spatial attention dominance groups occurred in the rostrum and rostral body of the corpus callosum. However, the directions of functional lateralization were not associated with the directions of white matter asymmetries. 2) The degree of language lateralization was predicted by SLF-III asymmetry and the rostral body of the corpus callosum, whereas the degree of spatial attention lateralization was predicted by the anterior midbody of the corpus callosum. Notably, the degree of each functional lateralization was positively correlated with the anterior and middle callosal connections, supporting the excitatory model of the corpus callosum. The results suggest that language lateralization is shaped by a combined effect of intra- and inter-hemispheric connections, whereas spatial attention lateralization relies more on interhemispheric connections.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":" 70","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Intra-hemispheric white matter asymmetries and inter-hemispheric connections underlying the lateralization of language production and spatial attention in left-handers\",\"authors\":\"Miaomiao Zhu, Xiao Wang, Xier Zhao, Qing Cai\",\"doi\":\"10.1162/nol_a_00153\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n Leftward language production and rightward spatial attention are salient features of functional organization in most humans, but their anatomical basis remains unclear. Interhemispheric connections and intra-hemispheric white matter asymmetries have been proposed as important factors underlying functional lateralization. To investigate the role of white matter connectivity in functional lateralization, we first identified 96 left-handers using visual half-field naming tasks. They were then divided into atypical and typical functional dominance based on the lateralization of brain activation in a word generation task (for language production) and a landmark task (for spatial attention). Using a novel fixel-based framework, we obtained fiber-specific properties of white matter pathways. Results showed that 1) differences between two language dominance groups occurred in the asymmetry of the superior longitudinal fasciculus-III (SLF-III), whereas differences between two spatial attention dominance groups occurred in the rostrum and rostral body of the corpus callosum. However, the directions of functional lateralization were not associated with the directions of white matter asymmetries. 2) The degree of language lateralization was predicted by SLF-III asymmetry and the rostral body of the corpus callosum, whereas the degree of spatial attention lateralization was predicted by the anterior midbody of the corpus callosum. Notably, the degree of each functional lateralization was positively correlated with the anterior and middle callosal connections, supporting the excitatory model of the corpus callosum. The results suggest that language lateralization is shaped by a combined effect of intra- and inter-hemispheric connections, whereas spatial attention lateralization relies more on interhemispheric connections.\",\"PeriodicalId\":3,\"journal\":{\"name\":\"ACS Applied Electronic Materials\",\"volume\":\" 70\",\"pages\":\"\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-07-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Electronic Materials\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1162/nol_a_00153\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1162/nol_a_00153","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
Intra-hemispheric white matter asymmetries and inter-hemispheric connections underlying the lateralization of language production and spatial attention in left-handers
Leftward language production and rightward spatial attention are salient features of functional organization in most humans, but their anatomical basis remains unclear. Interhemispheric connections and intra-hemispheric white matter asymmetries have been proposed as important factors underlying functional lateralization. To investigate the role of white matter connectivity in functional lateralization, we first identified 96 left-handers using visual half-field naming tasks. They were then divided into atypical and typical functional dominance based on the lateralization of brain activation in a word generation task (for language production) and a landmark task (for spatial attention). Using a novel fixel-based framework, we obtained fiber-specific properties of white matter pathways. Results showed that 1) differences between two language dominance groups occurred in the asymmetry of the superior longitudinal fasciculus-III (SLF-III), whereas differences between two spatial attention dominance groups occurred in the rostrum and rostral body of the corpus callosum. However, the directions of functional lateralization were not associated with the directions of white matter asymmetries. 2) The degree of language lateralization was predicted by SLF-III asymmetry and the rostral body of the corpus callosum, whereas the degree of spatial attention lateralization was predicted by the anterior midbody of the corpus callosum. Notably, the degree of each functional lateralization was positively correlated with the anterior and middle callosal connections, supporting the excitatory model of the corpus callosum. The results suggest that language lateralization is shaped by a combined effect of intra- and inter-hemispheric connections, whereas spatial attention lateralization relies more on interhemispheric connections.
期刊介绍:
ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric.
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