利用维生素 B12 作为高效生物催化剂合成各种螺-吡喃氧吲哚

Current Catalysis Pub Date : 2024-07-18 DOI:10.2174/0122115447320104240624045243

Reyhaneh Nadernia, G. Marandi, N. Hazeri, M. Maghsoodlou

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引用次数: 0

摘要

本研究旨在讨论在维生素 B12 存在的条件下，通过异汀、丙二腈和 CH-酸源反应合成各种螺吡喃-氧化吲哚衍生物。在维生素 B12 的存在下，靛红和丙二腈与作为 CH 酸的β-二羰基发生反应。总之，利用维生素 B12 作为生物催化剂合成螺-吡喃-氧化吲哚的一种新的有效方法已经得到证实。

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Synthesis of Various Spiro-Pyranooxoindoles Using Vitamin B12 as an Efficient Biocatalyst

The present study aims to discuss the synthesis of various spiropyrano- oxoindole derivatives through a reaction involving isatin, malononitrile, and a CH-acid source in the presence of vitamin B12. Eco-friendly solvents were utilized to synthesize the spiro-pyranooxoindole, resulting in high yields of all synthesized heterocyclic systems. Isatin and malononitrile were reacted with β-dicarbonyls as CH-acids in the presence of vitamin B12. The results indicate that vitamin B12 is highly effective in generating spiro-pyranooxoindole derivatives. All synthesized compounds closely match previously reported compounds. In conclusion, a new and effective method for synthesizing spiro-pyrano-oxoindole has been demonstrated using vitamin B12 as a biocatalyst.

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Current Catalysis

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