评估掺入柠檬香蒲精油的pluronic混合物的流变特性

Monique Guimarães de Sousa Carvalho, Bárbara Jaqueline De Carvalho Alves, Sidney Silva Simplicio, Guilherme Rodolfo Souza de Araujo, Joyce Kelly Marinheiro da Cunha Gonsalves
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引用次数: 0

摘要

这项研究开发了 Pluronic 与亲水性聚合物(壳聚糖、瓜尔胶、聚乙烯吡咯烷酮、聚乙烯醇)的聚合物混合物系统,用于输送柠檬香蒲精油(OECC)作为治疗材料的模型。根据这些亲水性聚合物对凝胶形成特性的影响进行了实验设计,并将 37 °C 下的凝胶时间作为反应进行评估。在选择了具有所需特性的配方后,添加了 OECC,并通过 pH 值、铺展性、粘度、流变学和化学分析对混合物进行了表征。壳聚糖是设计中确定的一种聚合物,可在较短时间内形成胶状混合物,且无沉淀。OECC 的存在使化学特性发生了微小的变化(在红外光谱中,混合物中油的 C=C 峰发生了位移;在 pH 值中,略微升高至 4.6);但流变特性没有发生变化,仅降低了铺展性,并保持了未添加 OECC 的混合物的假塑性行为。因此,在皮肤组织愈合过程中,混合物作为辅助材料的应用不会出现重大变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Avaliação das propriedades reológicas de blendas pluronic para a incorporação do óleo essencial de Cymbopogon citratus
In this work, systems of polymeric blends of Pluronic with hydrophilic polymers (chitosan, guar gum, polyvinyl pyrrolidone, polyvinyl alcohol) were developed to convey the essential oil of Cymbopogon citratus (OECC) as a model of healing material. An experimental design was carried out based on the influence of these hydrophilic polymers on the gel formation characteristics, evaluating the gelation time at 37 °C as a response. After selecting the formulation with the required characteristics, OECC was added and the blend was characterized by pH, spreadability, viscosity, rheology, and chemical analysis. Chitosan, a polymer defined by the design, provided the formation of the gelled blend in a shorter time and the absence of precipitates. The presence of OECC allows for discreet changes in chemical properties (in the infrared spectrum, displacement of the C=C peak of the oil in the blend; in pH, a slight increase to 4.6); but not in the rheological ones, only a reduction in spreadability and maintenance of the pseudoplastic behavior of the blend without the OECC. Therefore, no significant modifications would make applying the blend as an auxiliary material impossible in the cutaneous tissue healing process.
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